桥本甲状腺炎合并甲状腺乳头状癌的临床及病理学特征

发布时间：2018-11-22 10:43

【摘要】：目的分析桥本甲状腺炎(HT)合并甲状腺乳头状癌(PTC)的临床及病理学特征。方法 2013年10月至2015年10月共收治PTC患者297例。其中PTC合并HT者49例为研究组,男5例,女44例,24~67岁,45岁者27例。单纯PTC者248例为对照组,其中男60例,女188例,17~76岁,45岁者97例。分析两组患者的临床资料,包括性别、年龄、甲状腺弥漫性肿大、血清自身免疫抗体水平、是否存在包膜侵犯、肿瘤大小、术中冰冻病理准确率、中央区淋巴结转移、TNM分期,并行统计学分析。结果与对照组比较,研究组在性别、年龄、甲状腺弥漫性肿大、血清自身免疫抗体水平、中央区淋巴结转移方面差异均有统计学意义(P均0.05),而是否存在包膜侵犯、肿瘤大小、术中快速病理、TNM分期差异无统计学意义(P0.05)。结论 HT合并PTC多见于女性,发病年龄较早,可伴有甲状腺弥漫性肿大及血清自身免疫抗体的升高,早期即可出现淋巴结转移。提示对HT患者应定期复查,以利其早期病变的诊疗。
[Abstract]:Objective to analyze the clinical and pathological features of Hashimoto's thyroiditis (HT) complicated with papillary thyroid carcinoma (PTC). Methods 297 patients with PTC were treated from October 2013 to October 2015. There were 49 cases of PTC with HT in the study group, including 5 males, 44 females, 24 67 years old and 27 45 years old. 248 cases of simple PTC were used as control group, including 60 males, 188 females, 97 patients aged 1776 years and 45 years old. The clinical data of the two groups were analyzed, including sex, age, diffuse goiter, serum autoimmune antibody level, whether there was capsule invasion, tumor size, intraoperative frozen pathological accuracy, central lymph node metastasis, TNM staging. Parallel statistical analysis. Results compared with the control group, there were significant differences in sex, age, diffuse goiter, serum autoimmune antibody level and lymph node metastasis in the central region in the study group (all P 0.05). There was no significant difference in tumor size, intraoperative pathology and TNM staging (P0.05). Conclusion HT combined with PTC is more common in women with earlier onset age, accompanied by diffuse goiter and increased serum autoimmune antibody, and lymph node metastasis may occur in the early stage. It is suggested that the patients with HT should be rechecked regularly to facilitate the diagnosis and treatment of their early lesions.
【作者单位】：山东大学第二医院甲状腺外科;
【基金】：山东大学第二医院种子基金(S2015010007)
【分类号】：R736.1;R581.4

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