关于糖尿病患者结直肠癌发生风险性的Meta分析
发布时间：2018-11-22 07:34
【摘要】：目的更新既往的有关的研究资料,使用循证医学的方法,为进一步系统的评价糖尿病(Diabetes mellitus, DM)和结直肠癌(Colorectal cancer, CRC)之间的发生风险,以进一步阐明糖尿病是否是促进结直肠恶性肿瘤发生发展的相关风险的促进要素之一,借以为糖尿病人群进行结直肠恶性肿瘤的早期排查提供进一步的临床根据,从而对能够使糖尿病患者早期进行恶性肿瘤的筛查,做到能够早发现、早治疗,从而使糖尿病病患的生存质量得到改善。方法通过计算机网络检索1994年1月1日至2014年10月31日PubMed、 MEDLINE、EMBase、中国知网、维普、万方等中英文数据库中公开发表的探讨糖尿病与结直肠恶性肿瘤关系的大型队列研究或者病例对照研究的文献,根据制定的统一的文献纳入以及剔除的标准进行文献的筛选、核对等,然后提取相关数据资料,最后通过采用Review Manager5.3统计学软件完成Meta分析,并通过比值比(Odds ratio, OR)作为效应量对筛选后的文献数据进行合并分析。结果经过文献的筛选、排除等步骤后纳入研究的共计16篇,共计积累研究病例1723632例,其中研究组103753例,对照组1619879例。经过Review Manager 5.3软件进行数据的处理后,Meta分析结果显示：OR=1.38,95%可信区间(1.31,1.45),进行合并效应检验后Z=12.52,P0.00001。数据结果提示糖尿病患者结直肠恶性肿瘤的发生率较对照组偏高,差异具有统计学的意义。结论结直肠恶性肿瘤的发生和糖尿病具有高度的关联性,糖尿病是促进患者结直肠恶性肿瘤的危险因素之一。
[Abstract]:Objective to evaluate the risk of diabetes mellitus (Diabetes mellitus, DM) and colorectal cancer (Colorectal cancer, CRC) by updating previous relevant research data and using evidence-based medicine (EBM) methods to further evaluate the risk of diabetes mellitus (DM) and colorectal cancer (Colorectal cancer, CRC). To further clarify whether diabetes is one of the factors contributing to the risk associated with the development of colorectal malignancies, and to provide further clinical evidence for the early detection of colorectal malignancies in diabetics. It can make the patients with diabetes cancer screening early, so that early detection, early treatment, so as to improve the quality of life of patients with diabetes. Methods from January 1, 1994 to October 31, 2014, PubMed, MEDLINE,EMBase, China knowledge Network, Weip, was searched by computer network. The literature published in Wanfang and other Chinese and English databases on large-scale cohort studies or case-control studies on the relationship between diabetes mellitus and colorectal malignant tumors is screened according to the unified criteria for inclusion and elimination of the established documents. Finally, the Meta analysis was completed by using Review Manager5.3 software, and the selected literature data were combined by ratio (Odds ratio, OR) as the effect quantity. Results A total of 16 cases were included in the study, including 103753 cases in the study group and 1619879 cases in the control group. After processing the data by Review Manager 5.3, the results of Meta analysis showed that the confidence interval of OR=1.38,95% (1.31 卤1.45), and the combination effect test, Z _ (12.52) (P _ (0.00001). The data showed that the incidence of colorectal malignant tumor in diabetic patients was higher than that in the control group, and the difference was statistically significant. Conclusion there is a high correlation between colorectal malignant tumor and diabetes mellitus. Diabetes is one of the risk factors to promote colorectal malignant tumor.
【学位授予单位】：广西医科大学
【学位级别】：硕士
【学位授予年份】：2015
【分类号】：R587.1;R735.34
本文编号：2348515
[Abstract]:Objective to evaluate the risk of diabetes mellitus (Diabetes mellitus, DM) and colorectal cancer (Colorectal cancer, CRC) by updating previous relevant research data and using evidence-based medicine (EBM) methods to further evaluate the risk of diabetes mellitus (DM) and colorectal cancer (Colorectal cancer, CRC). To further clarify whether diabetes is one of the factors contributing to the risk associated with the development of colorectal malignancies, and to provide further clinical evidence for the early detection of colorectal malignancies in diabetics. It can make the patients with diabetes cancer screening early, so that early detection, early treatment, so as to improve the quality of life of patients with diabetes. Methods from January 1, 1994 to October 31, 2014, PubMed, MEDLINE,EMBase, China knowledge Network, Weip, was searched by computer network. The literature published in Wanfang and other Chinese and English databases on large-scale cohort studies or case-control studies on the relationship between diabetes mellitus and colorectal malignant tumors is screened according to the unified criteria for inclusion and elimination of the established documents. Finally, the Meta analysis was completed by using Review Manager5.3 software, and the selected literature data were combined by ratio (Odds ratio, OR) as the effect quantity. Results A total of 16 cases were included in the study, including 103753 cases in the study group and 1619879 cases in the control group. After processing the data by Review Manager 5.3, the results of Meta analysis showed that the confidence interval of OR=1.38,95% (1.31 卤1.45), and the combination effect test, Z _ (12.52) (P _ (0.00001). The data showed that the incidence of colorectal malignant tumor in diabetic patients was higher than that in the control group, and the difference was statistically significant. Conclusion there is a high correlation between colorectal malignant tumor and diabetes mellitus. Diabetes is one of the risk factors to promote colorectal malignant tumor.
【学位授予单位】：广西医科大学
【学位级别】：硕士
【学位授予年份】：2015
【分类号】：R587.1;R735.34
【参考文献】
相关期刊论文 前1条
1 康怡;曹悦鞍;;糖尿病及相关药物与肿瘤的关系[J];海军总医院学报;2011年04期
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