2种口服降糖药物联合胰岛素治疗初诊2型糖尿病的临床对比研究

发布时间：2018-11-23 18:12

【摘要】：目的:探讨2种口服降糖药物分别联合人工合成胰岛素对初诊2型糖尿病(T2DM)的患者血糖指标、胰岛β细胞功能及低血糖发生率的影响。方法:研究对象选取某院2013年4月-2015年12月收治初诊T2DM患者共120例,以随机数字表法分为A组(60例)和B组(60例),分别在甘精胰岛素应用基础上加用罗格列酮和格列美脲辅助治疗;比较2组患者血糖达标时间,胰岛素用量,治疗前后BMI水平、血糖指标水平、胰岛β细胞功能指标水平、低血糖及心血管疾病发生率等。结果:2组患者血糖达标时间和胰岛素用量比较差异无显著性意义(P0.05);B组患者治疗后BMI水平显著低于A组(P0.05);2组患者治疗后血糖和胰岛β细胞指标水平组间比较差异无显著性意义(P0.05);同时B组患者低血糖发生率显著低于A组(P0.05);2组患者心血管疾病发生率比较差异无显著性意义(P0.05)。结论:罗格列酮和格列美脲分别联合人工合成胰岛素治疗初诊T2DM临床疗效接近,但格列美脲口服可有效减少体质量增加量,降低低血糖发生风险,更具临床应用价值。
[Abstract]:Aim: to investigate the effects of two oral hypoglycemic drugs combined with synthetic insulin on blood glucose, islet 尾 cell function and hypoglycemia in newly diagnosed type 2 diabetes mellitus (T2DM) patients. Methods: from April 2013 to December 2015, 120 patients with T2DM were randomly divided into two groups: group A (n = 60) and group B (n = 60). The adjuvant therapy of rosiglitazone and glimepiride was added on the basis of insulin glargine. The blood glucose standard time, insulin dosage, BMI level, blood glucose index, islet 尾 -cell function index, hypoglycemia and the incidence of cardiovascular disease were compared between the two groups. Results: there was no significant difference in blood glucose standard time and insulin dosage between the two groups (P0.05 BMI level in); B group was significantly lower than that in A group (P0.05); There was no significant difference in blood glucose and islet 尾 -cell levels between the two groups after treatment (P0.05), while the incidence of hypoglycemia in group B was significantly lower than that in group A (P0.05). There was no significant difference in the incidence of cardiovascular disease between the two groups (P0.05). Conclusion: the clinical efficacy of rosiglitazone and glimepiride combined with synthetic insulin in the treatment of newly diagnosed T2DM is close, but oral glimepiride can effectively reduce the increase of body mass, reduce the risk of hypoglycemia, and has more clinical application value.
【作者单位】：兰州大学第一医院药剂科;兰州大学第一医院血液透析科;兰州大学第一医院内科;
【分类号】：R587.1

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