视网膜中央动脉与颈内动脉超声检查在糖尿病视网膜病变早期诊断中的应用价值
发布时间：2018-12-06 08:47
【摘要】：目的本研究通过彩色多普勒超声检查视网膜中央动脉(Central retinal artery,CRA)及颈内动脉(Internal carotid artery,ICA),研究糖尿病(Diabetes mellitus,DM)患者与健康志愿者的CRA与ICA的血流动力学特征,并分析其差异,以探讨超声检查在糖尿病视网膜病变(Diabetic retinopathy,DR)早期诊断中的应用价值。方法选取DM患者62例(共124只眼)作为病例组,健康志愿者37例(共74只眼)作为对照组,根据眼底摄片结果将DM患者分为非糖尿病视网膜病变(Non-diabetic retinopathy,NDR)组及糖尿病视网膜病变(Diabetic retinopathy,DR)组,其中NDR组27例(共54只眼),DR组35例(共70只眼)。分别对健康志愿者及DM患者的视网膜中央动脉及颈内动脉行超声检查,检测并对比分析其收缩期峰值流速(Peak systolic velocity,PSV)、舒张末期流速(End-diastolic velocity,EDV)与阻力指数(Resistance index,RI)。结果DR组、NDR组与对照组视网膜中央动脉的PSV分别为:7.93±1.60cm/s、10.65±2.07cm/s、11.53±2.07cm/s,EDV分别为2.71±0.57cm/s、4.14±0.83cm/s、4.72±1.07cm/s,RI分别为0.66±0.06、0.61±0.03、0.59±0.05;DR组、NDR组与对照组颈内动脉的PSV分别为:52.64±9.00cm/s、57.62±6.11cm/s、56.38±11.19cm/s,EDV分别为20.34±5.17cm/s、24.83±5.14cm/s、24.42±5.64cm/s,RI分别为0.62±0.08、0.57±0.07、0.57±0.06。NDR组与对照组的视网膜中央动脉各血流动力学参数比较,NDR组的PSV与EDV均下降,RI升高,差异均有统计学意义(PSVP0.05,EDV及RI P0.01)。DR组与NDR组、对照组的视网膜中央动脉各血流动力学参数比较,DR组的PSV与EDV均下降,RI升高,差异均有统计学意义(P0.01)。NDR组与对照组的颈内动脉PSV、EDV及RI比较,差异均无统计学意义(P0.05)。DR组与NDR组、对照组的颈内动脉各血流动力学参数比较,DR组PSV、EDV下降,RI升高,差异均有统计学意义(与NDR组比较,PSV、EDV及RI P0.01;与对照组比较,PSVP0.05,EDV及RI P0.01)。结论超声检查可显示DM患者视网膜中央动脉及颈内动脉的血流动力学参数PSV、EDV及RI,其血流动力学的改变(如PSV下降、EDV下降及RI升高等)均有助于早期诊断DR,可为临床早期诊断及治疗DR提供更多的诊断信息。
[Abstract]:Objective to study the hemodynamic characteristics of CRA and ICA in patients with diabetes mellitus (Diabetes mellitus,DM) and healthy volunteers by color Doppler ultrasound (CDFI) examination of central retinal artery (Central retinal artery,CRA) and internal carotid artery (Internal carotid artery,ICA). To explore the value of ultrasonography in the early diagnosis of diabetic retinopathy (Diabetic retinopathy,DR). Methods Sixty-two DM patients (124 eyes) were selected as the case group and 37 healthy volunteers (74 eyes) as the control group. According to the results of fundus radiography, the patients with DM were divided into non-diabetic retinopathy (Non-diabetic retinopathy,). NDR group and diabetic retinopathy (Diabetic retinopathy,DR) group, NDR group 27 cases (54 eyes), DR 35 cases (70 eyes). The central retinal artery and internal carotid artery of healthy volunteers and patients with DM were examined by ultrasound. The peak systolic velocity (Peak systolic velocity,PSV), end-diastolic velocity (End-diastolic velocity,EDV) and resistance index (Resistance index,) were detected and compared. RI). Results the PSV of central retinal artery in DR group, NDR group and control group were 7.93 卤1.60 cm / s and 10.65 卤2.07 cm / s respectively. The PSV of central retinal artery in DR group, NDR group and control group were 2.71 卤0.57 cm / s, 4.14 卤0.83 cm / s and 4.72 卤1.07 cm / s, respectively. RI was 0.66 卤0.06U 0.61 卤0.03U 0.59 卤0.05; The PSV of internal carotid artery in DR group, NDR group and control group were 52.64 卤9.00 cm / s, 57.62 卤6.11 cm / s, 56.38 卤11.19 cm / s EDV, respectively, which were 20.34 卤5.17 cm / s (24.83 卤5.14 cm / s) and 24.42 卤5.64 cm / s, respectively. The hemodynamic parameters of the central retinal artery in the RI group were 0.62 卤0.08 and 0.57 卤0.07 卤0.57 卤0.57 卤0.06.NDR, respectively. The PSV and EDV in the NDR group were significantly lower than those in the control group (PSVP0.05,). The hemodynamic parameters of central retinal artery in EDV and RI P0.01). DR group and NDR group were lower than those in NDR group. PSV and EDV in DR group were decreased, RI was increased in DR group. There was no significant difference in PSV,EDV and RI between the). NDR group and the control group (P0.05 between the). DR group and the NDR group, and the comparison of the internal carotid artery hemodynamic parameters between the control group and the control group). PSV,EDV decreased and RI increased in DR group (compared with NDR group, PSV,EDV and RI P 0.01); Compared with the control group, PSVP0.05,EDV and RI P0.01). Conclusion Ultrasound can show the hemodynamic parameters of central retinal artery and internal carotid artery in patients with DM. The changes of hemodynamics in PSV,EDV and RI, (such as decreased PSV, decreased EDV and increased RI) are helpful for the early diagnosis of DR,. It can provide more diagnostic information for early diagnosis and treatment of DR.
【学位授予单位】：广西医科大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R587.2;R774.1;R445.1
本文编号：2365770
[Abstract]:Objective to study the hemodynamic characteristics of CRA and ICA in patients with diabetes mellitus (Diabetes mellitus,DM) and healthy volunteers by color Doppler ultrasound (CDFI) examination of central retinal artery (Central retinal artery,CRA) and internal carotid artery (Internal carotid artery,ICA). To explore the value of ultrasonography in the early diagnosis of diabetic retinopathy (Diabetic retinopathy,DR). Methods Sixty-two DM patients (124 eyes) were selected as the case group and 37 healthy volunteers (74 eyes) as the control group. According to the results of fundus radiography, the patients with DM were divided into non-diabetic retinopathy (Non-diabetic retinopathy,). NDR group and diabetic retinopathy (Diabetic retinopathy,DR) group, NDR group 27 cases (54 eyes), DR 35 cases (70 eyes). The central retinal artery and internal carotid artery of healthy volunteers and patients with DM were examined by ultrasound. The peak systolic velocity (Peak systolic velocity,PSV), end-diastolic velocity (End-diastolic velocity,EDV) and resistance index (Resistance index,) were detected and compared. RI). Results the PSV of central retinal artery in DR group, NDR group and control group were 7.93 卤1.60 cm / s and 10.65 卤2.07 cm / s respectively. The PSV of central retinal artery in DR group, NDR group and control group were 2.71 卤0.57 cm / s, 4.14 卤0.83 cm / s and 4.72 卤1.07 cm / s, respectively. RI was 0.66 卤0.06U 0.61 卤0.03U 0.59 卤0.05; The PSV of internal carotid artery in DR group, NDR group and control group were 52.64 卤9.00 cm / s, 57.62 卤6.11 cm / s, 56.38 卤11.19 cm / s EDV, respectively, which were 20.34 卤5.17 cm / s (24.83 卤5.14 cm / s) and 24.42 卤5.64 cm / s, respectively. The hemodynamic parameters of the central retinal artery in the RI group were 0.62 卤0.08 and 0.57 卤0.07 卤0.57 卤0.57 卤0.06.NDR, respectively. The PSV and EDV in the NDR group were significantly lower than those in the control group (PSVP0.05,). The hemodynamic parameters of central retinal artery in EDV and RI P0.01). DR group and NDR group were lower than those in NDR group. PSV and EDV in DR group were decreased, RI was increased in DR group. There was no significant difference in PSV,EDV and RI between the). NDR group and the control group (P0.05 between the). DR group and the NDR group, and the comparison of the internal carotid artery hemodynamic parameters between the control group and the control group). PSV,EDV decreased and RI increased in DR group (compared with NDR group, PSV,EDV and RI P 0.01); Compared with the control group, PSVP0.05,EDV and RI P0.01). Conclusion Ultrasound can show the hemodynamic parameters of central retinal artery and internal carotid artery in patients with DM. The changes of hemodynamics in PSV,EDV and RI, (such as decreased PSV, decreased EDV and increased RI) are helpful for the early diagnosis of DR,. It can provide more diagnostic information for early diagnosis and treatment of DR.
【学位授予单位】：广西医科大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R587.2;R774.1;R445.1
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