血清性激素结合球蛋白与男性2型糖尿病患者下肢血管病变的关系

发布时间：2018-12-11 11:44

【摘要】：目的探讨男性2型糖尿病(T2DM)患者血清性激素结合球蛋白(SHBG)水平与下肢血管病变的关系。方法 170例T2DM患者根据下肢血管超声结果分为T2DM患者无下肢血管病变组(A组)86例和T2DM患者下肢血管病变组(B组)84例,并选取80例同期来院体检的男性健康者为对照组(NC组)。采用电化学发光法检测各组空腹血清SHBG,检测空腹血糖(FPG)、血脂、糖化血红蛋白(Hb A1c)、餐后2 h血糖(2 h PG)、胰岛素,分析上述指标与T2DM患者下肢血管病变的关系。结果 3组血清SHBG水平依次为:NC组[(59.49±12.98)μg/L]A组[(45.69±14.01)μg/L]B组[(31.14±10.03)μg/L(P0.01,P0.05)];相关分析显示,血清SHBG与病程、体重指数(BMI)、腰臀比、总胆固醇(TC)、甘油三酯(TG)、Hb A1c、胰岛素抵抗指数(HOMA-IR)负相关(r值分别为-0.071、-0.439、-0.310、-0.202、-0.213、-0.142、-0.395,P0.05或P0.01),与LDL-C、2 h PG正相关(r=0.248,0.441;P0.05)。回归分析显示,血清SHBG水平是男性T2DM患者下肢血管病变的主要影响因素之一(P0.05)。结论低SHBG水平与男性T2DM患者下肢血管病变的发生密切相关。
[Abstract]:Objective to investigate the relationship between serum sex hormone binding globulin (SHBG) levels and lower extremity vascular lesions in male patients with type 2 diabetes mellitus (T2DM). Methods according to the results of ultrasound, 170 patients with T2DM were divided into two groups: 86 patients without lower extremity vascular lesion (group A) and 84 patients with lower extremity vascular disease (group B) with T2DM. 80 healthy men were selected as control group (NC group). Fasting blood glucose (FPG), blood lipid (FPG), glycosylated hemoglobin (Hb A1c), 2 h postprandial blood glucose (2 h PG), insulin) were measured by electrochemiluminescence (ECL). To analyze the relationship between the above indexes and lower extremity vascular lesion in patients with T2DM. Results the serum SHBG levels in NC group [(59.49 卤12.98) 渭 g / L] A group [(45.69 卤14.01) 渭 g / L] B group [(31.14 卤10.03) 渭 g / L (P 0.05)]; Correlation analysis showed that serum SHBG was negatively correlated with the course of disease, body mass index (BMI), waist-hip ratio (WHR), total cholesterol (TC), triglyceride (TG), Hb A1c), insulin resistance index (HOMA-IR) (r = -0.071 卤0.439, r = -0.071). -0.310 ~ (10) -0.202 ~ (-1) -0.213 ~ (13) -0.142 ~ (2 +) -0.395 (P0.05 or P0.01), which was positively correlated with LDL-C,2 h PG (r = 0.248 ~ (0.441); P0.05). Regression analysis showed that serum SHBG level was one of the main influencing factors of lower extremity vascular disease in male patients with T2DM (P0.05). Conclusion low SHBG level is closely related to the occurrence of lower extremity vascular disease in male patients with T2DM.
【作者单位】：三峡大学仁和医院检验科;
【分类号】：R587.2

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