MicroRNA在强直性脊柱炎成骨、破骨机制中的作用

发布时间：2018-12-14 09:30

【摘要】：炎性骨破坏和新骨形成是强直性脊柱炎(ankylosing spondylitis,AS)的典型病理改变,AS早期以炎症为主,晚期出现异位骨化和骨破坏,异位骨化和骨破坏两种矛盾的表现反映了强直性脊柱炎患者成骨与破骨过程之间的动态平衡被打破。其发病机制尚不完全清楚,目前研究认为,AS复杂的新骨形成机制与Wnt/β-catenin信号通路及BMP/Smads通路密切相关,而破骨细胞则在骨破坏过程中起重要作用,RANKL/RANK/OPG系统中的细胞因子是调控破骨细胞分化成熟的关键因子。Micro RNA可调节成骨细胞、软骨细胞和破骨细胞的分化与功能,是骨形成、骨吸收、骨重塑和修复过程中的关键调节因子。研究MicroRNA在强直性脊柱炎成骨、破骨机制中的作用,可为AS的诊断和治疗提供新的依据。
[Abstract]:Inflammatory bone destruction and new bone formation are typical pathological changes of ankylosing spondylitis (ankylosing spondylitis,AS). Inflammation is predominant in early stage of AS and ectopic ossification and bone destruction occur in late stage. The two contradictory manifestations of ectopic ossification and bone destruction reflect that the dynamic balance between osteogenesis and osteoclast in patients with ankylosing spondylitis is broken. The pathogenesis of osteoclast is not completely clear. At present, the complex new bone formation mechanism of AS is closely related to Wnt/ 尾-catenin signaling pathway and BMP/Smads pathway, while osteoclast plays an important role in the process of bone destruction. Cytokines in RANKL/RANK/OPG system are the key factors to regulate the differentiation and maturation of osteoclasts. Micro RNA can regulate the differentiation and function of osteoblasts, chondrocytes and osteoclasts, which are bone formation and bone resorption. Key regulatory factors in bone remodeling and repair. To study the role of MicroRNA in osteogenesis and osteoclast of ankylosing spondylitis may provide a new basis for the diagnosis and treatment of AS.
【作者单位】：北京中医药大学;中日友好医院临床医学研究所;中日友好医院中医风湿病科免疫炎性疾病北京市重点实验室;
【基金】：国家自然科学基金青年项目(81403378) 中日友好医院青年科技英才培养计划(2014-QNYC-B-02)
【分类号】：R593.23

【相似文献】