中医辨证论治联合甲氨蝶呤治疗类风湿关节炎的近远期疗效研究

发布时间：2018-12-18 14:34

【摘要】：目的:观察中医辨证论治联合甲氨蝶呤治疗类风湿关节炎(RA)的近远期疗效。方法:将86例RA患者分为对照组和治疗组各43例。对照组给予甲氨蝶呤治疗,治疗组在此基础上予以中医辨证论治,比较两组疗效、临床症状、实验室指标、Th17/Treg细胞变化情况与复发率。结果:观察组总有效率为90.70%高于对照组的72.09%,6个月复发率为6.98%低于对照组23.26%,差异有统计学意义(P0.05);观察组治疗后28个关节疼痛数、关节肿胀、晨僵时间低于对照组,ESR、RF、IL-1、TNF-α、CRP低于对照组,差异有统计学意义(P0.05);观察组治疗后Th17/CD4+T细胞低于对照组,Treg/CD4+T细胞高于对照组,组间比较有差异(P0.05)。结论:采用中医辨证论治联合甲氨蝶呤治疗RA可改善机体免疫紊乱,缓解临床症状,降低疾病复发率。
[Abstract]:Objective: to observe the short-and long-term curative effect of treating rheumatoid arthritis (RA) with TCM syndrome differentiation and methotrexate. Methods: 86 patients with RA were divided into control group (43 cases) and treatment group (43 cases). The control group was treated with methotrexate, the treatment group was treated with TCM syndrome differentiation, and the curative effect, clinical symptoms, laboratory index, Th17/Treg cell change and recurrence rate were compared between the two groups. Results: the total effective rate of the observation group was 90.70% higher than that of the control group 72.09%, the recurrence rate of 6 months was 6.98% lower than that of the control group 23.26, the difference was statistically significant (P0.05). The number of joint pain, joint swelling, morning stiffness time, ESR,RF,IL-1,TNF- 伪 and CRP in the observation group were lower than those in the control group after treatment (P0.05). After treatment, Th17/CD4 T cells and Treg/CD4 T cells in the observation group were lower than those in the control group, and there was significant difference between the two groups (P0.05). Conclusion: the treatment of RA with TCM syndrome differentiation and methotrexate can improve the immune disorder, relieve clinical symptoms and reduce the recurrence rate of the disease.
【作者单位】：内江市中医医院中医内科;
【分类号】：R593.22

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