CXCL4在系统性硬化病患者血清中的水平及临床意义
[Abstract]:Aim: to detect the level of CXC chemokine ligand 4 (CXCL4) in serum of patients with systemic sclerosis (systemic sclerosis, SSc) and to study its relationship with clinical features. Methods: the serum CXCL4 levels in 30 patients with systemic sclerosis and 20 healthy controls were detected by enzyme-linked immunosorbent assay (ELISA). The serum CXCL4 levels were evaluated with (Interstitial lung disease,ILD, the degree of skin sclerosis, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), and the course of disease. Pulmonary hypertension, disease severity and other clinical indicators. Results: 1the level of serum CXCL4 in SSC group was higher than that in healthy control group (13309.4 卤2993.3 vs7420.3 卤2042.7 pg/ml,P=0.000); There was no significant difference in CXCL4 levels between diffuse sclerosis group and localized sclerosis group (12922.5 卤3293.1 vs 14083.2 卤2231.3 PG / ml 0.293). The incidence of ILD (SSc-ILD) in SSc patients with elevated CXCL4 was significantly higher than that in patients without increased CXCL4 [(14 / 16) 87.5% vs (7 / 14) 50% P0. 046], but age, sex, course of disease, MRSS score, other organs were involved. The serum CXCL4 level in patients with SSc-ILD was significantly higher than that in patients with SSc without ILD (14173.4 卤2616.6vs 11293.4 卤2971.6 pg/ml,P=0.013). However, there was no significant difference between the involvement of finger ulcer, digestive tract involvement, muscle involvement, pulmonary hypertension and other organs. 4 the serum CXCL4 level was positively correlated with lung high-resolution CT (High Resolution CT, HRCT) score in patients with SSC (r = 0.647, P < 0.05). There was a positive correlation between P0. 002 and improved Rodman's skin score (modified rodman skin score, MRSS) (r = 0. 367, P = 0. 046). But there was no significant correlation with ESR, CRP, Medsger severity score, pulmonary systolic blood pressure and HAQ score. The changes of serum CXCL4 level before and after treatment: the serum CXCL4 level and pulmonary HRCT score decreased in 4 patients with SSc after 6 months of treatment with oral hormone and intravenous cyclophosphamide. Conclusion: 1. Serum CXCL4 level in SSc patients was significantly higher than that in healthy controls, but there was no significant difference between diffuse type and localized type. 2. SSc patients with elevated serum CXCL4 were more likely to be associated with ILD,. The serum CXCL4 level of SSc-ILD patients was significantly higher than that of SSc patients without ILD, which was positively correlated with skin MRSS score and chest HRCT score, but had no significant correlation with the degree of disease activity and severity. The increase of serum CXCL4 level in patients with SSc may be related to skin and ILD lesions.
【学位授予单位】:广西医科大学
【学位级别】:硕士
【学位授予年份】:2016
【分类号】:R593.2
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