2型糖尿病患者的血管并发症与血糖控制及其危险因素的相互关系

发布时间：2018-12-22 08:06

【摘要】：目的通过观察2型糖尿病患者血糖控制,以了解糖尿病血管并发症及其相关危险因素之间有无差别,并进行回归分析进一步明确糖尿病患者大血管与微血管并发症相关危险因素的异同,以期指导临床。方法将258例确诊2型糖尿病的住院患者,根据入院血糖控制情况以糖化血红蛋白(Hb A1c)7%为观察组,Hb A1c≤7%为对照组。观察两组间大血管并发症颈动脉内-中膜厚度、微血管并发症尿微量白蛋白/肌酐比值、空腹C肽、胰岛素抵抗指数(HOMA-IR)、纤维蛋白单体、血清25羟维生素D3[25(OH)D3]、胱抑素C、C反应蛋白、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、体重指数及患者年龄、发病时间等有无差异,并对大血管及微血管并发症分别进行二分类Logistic回归分析。结果两组间血糖高低未见与相关炎症指标有关,大血管及微血管并发症差异无统计学意义,但HDL-C,LDL-C及C肽、HOMA-IR、年龄均差异有统计学意义(P=0.002、0.001、0.001、0.001、0.019)。微血管并发症的二分类Logistic回归分析提示与25(OH)D3、胱抑素C有关。二分类Logistic回归分析提示大血管并发症与低密度脂蛋白胆固醇、胱抑素C有关。结论胱抑素C对糖尿病大血管及微血管并发症有预测意义。患者摄入足量维生素D对微血管并发症及LDL-C的达标对大血管并发症的控制与发生有积极意义。
[Abstract]:Objective to investigate whether there is a difference between diabetic vascular complications and related risk factors by observing the control of blood glucose in patients with type 2 diabetes. The risk factors related to macrovascular and microvascular complications in diabetic patients were further identified by regression analysis in order to guide clinical practice. Methods two hundred and fifty-eight inpatients with type 2 diabetes mellitus were divided into two groups: Hb A1c (7%) and Hb A1c 鈮，

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