二甲双胍对2型糖尿病患者血清Klotho水平的影响

发布时间：2018-12-23 11:17

【摘要】：目的探讨二甲双胍对2型糖尿病(T2DM)患者血清Klotho(KL)水平的影响。方法选择89例健康人为对照组(A组)。87例T2DM患者随机分为二甲双胍治疗组(B组)、格列美脲治疗组(C组)。采用ELISA测定T2DM患者及健康人群KL水平。观察二甲双胍治疗后T2DM患者KL水平变化。结果 1T2DM组KL水平低于A组〔(2.62±0.51)vs(5.21±0.72)ng/ml,P0.01〕;2血清KL水平与空腹血糖(FPG)、糖化血红蛋白(Hb A1c)、白细胞介素(IL)-6、稳态模型胰岛素抵抗指数(HOMA-IR)、空腹胰岛素(Fins)、肿瘤坏死因子(TNF)-α、甘油三酯(TG)呈负相关(r分别为-0.592、-0.616、-0.517、-0.598、-0.526、-0.638、-0.512,P0.05或P0.01);与超氧化物歧化酶(SOD)正相关(r=0.523,P0.05);3经二甲双胍治疗后KL水平明显升高(P0.05);4HOMA-IR、TNF-α是影响KL水平的独立相关因素。结论 T2DM患者血清KL水平降低。二甲双胍增加T2DM患者胰岛素敏感性同时增加KL水平。
[Abstract]:Objective to investigate the effect of metformin on serum Klotho (KL) level in patients with type 2 diabetes mellitus (T2DM). Methods Eighty-nine healthy persons were selected as control group (group A) and 87 patients with T2DM were randomly divided into metformin group (group B) and glimepiride group (group C). ELISA was used to measure the level of KL in T2DM patients and healthy people. To observe the changes of KL level in patients with T2DM after metformin treatment. Results the level of KL in 1T2DM group was lower than that in group A (2.62 卤0.51) vs (5.21 卤0.72 ng/ml,P0.01). 2Serum KL level and fasting blood glucose (FPG), glycosylated hemoglobin (Hb A1c), interleukin (IL) 6, steady-state model insulin resistance index (HOMA-IR), fasting insulin (Fins), tumor necrosis factor (TNF)-伪, fasting insulin (Fins), and insulin resistance index (HOMA-IR). The (TG) of triglyceride was negatively correlated (r = -0.592 ~ 0.616 ~ (-1) -0.517 ~ (-1) -0.559 ~ (8) ~ (-0.526) ~ (-0.638) (P0.05 or P ~ (0.01). The level of KL was significantly increased after metformin treatment (P0.05); (4) HOMA-IRN TNF- 伪 was an independent factor affecting the level of KL. Conclusion the level of serum KL in patients with T2DM is decreased. Metformin increased insulin sensitivity and increased KL levels in patients with T2DM.
【作者单位】：三峡大学仁和医院;
【分类号】：R587.1

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