黄酮类物质预防骨质疏松症的研究进展

发布时间：2018-12-26 18:38

【摘要】：随着我国步入老龄化社会,骨质疏松症屡见不鲜,已经成为严峻的公共卫生及社会问题。老年人骨含量降低,易导致骨脆性、骨折风险度上升,所以骨质疏松症应该及时诊断。但骨质疏松症治疗的难点在于治疗滞后,骨质病变前期的临床现象不易被发现,如何有效预防骨质疏松症成为医学界亟待解决的问题。黄酮类物质广泛存在于蔬菜、水果和药用植物中,含量丰富,具有多种生物活性,毒副作用小。大量研究证明,黄酮类物质可以促进成骨细胞增殖、促进骨细胞矿化、抑制破骨细胞骨吸收、增加骨峰值、减少骨流失,可有效预防骨质疏松症,保护骨健康。本文重在总结黄酮类物质防止骨质疏松症的分子机制、黄酮类物质预防骨质疏松症作用机理等研究进展,为预防骨质疏松症的保健食品和药品的开发提供理论依据。
[Abstract]:Osteoporosis has become a serious public health and social problem since China stepped into an aging society. Lower bone content in the elderly leads to brittleness and increased fracture risk, so osteoporosis should be diagnosed in time. However, the difficulty in the treatment of osteoporosis lies in the lag of treatment, and the clinical phenomenon of pre-osteoporosis is not easy to be found. How to effectively prevent osteoporosis has become an urgent problem to be solved in the medical field. Flavonoids are widely found in vegetables, fruits and medicinal plants. A large number of studies have proved that flavonoids can promote the proliferation of osteoblasts, promote the mineralization of osteocytes, inhibit the bone resorption of osteoclasts, increase the peak value of bone, reduce bone loss, effectively prevent osteoporosis and protect bone health. In this paper, the molecular mechanism of flavonoids in preventing osteoporosis and the mechanism of flavonoids in preventing osteoporosis are summarized in order to provide theoretical basis for the development of health food and medicine for the prevention of osteoporosis.
【作者单位】：北京工商大学北京食品营养与人类健康高精尖创新中心食品添加剂与配料北京高校工程研究中心;
【基金】：国家自然科学基金项目(31501480) 北京市留学人才科技活动项目优秀类项目
【分类号】：R580

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