血清COMP蛋白、转甲状腺素蛋白及维生素D检测在类风湿关节炎中的诊断价值

发布时间：2018-12-27 11:45

【摘要】：目的探讨血清软骨寡聚基质蛋白(COMP)、转甲状腺素蛋白(TTR)水平及25羟维生素D[25(OH)D]对早期类风湿关节炎(RA)的诊断价值。方法早期RA组患者58例、其他风湿病组及正常对照组各34例,采用酶联免疫吸附试验(ELISA)检测血清COMP、TTR及25(OH)D水平并行方差分析,比较COMP、TTR单独及联合检测对RA的诊断意义。结果血清COMP、TTR水平在早期RA组较其他风湿病组及正常对照组明显升高(P0.05),25(OH)D浓度在早期RA组较其他风湿病组及正常对照组明显降低(P0.05),三因子的其他风湿病组与正常对照组间差异无统计学意义(P0.05)。COMP、TTR单独检测,TTR敏感度高,COMP特异度较强。联合检测特异度较单因子检测升高。结论血清COMP、TTR可作为早期RA诊断的生物学标记,联合检测在早期RA中应用更佳。
[Abstract]:Objective to investigate the diagnostic value of serum oligo-matrix protein (COMP), transthyroxine (COMP),) (TTR) and 25 hydroxyvitamin D [25 (OH) D] in early rheumatoid arthritis (RA). Methods 58 cases of early RA group, 34 cases of other rheumatism group and 34 cases of normal control group were enrolled. The serum COMP,TTR and 25 (OH) D levels were detected by enzyme linked immunosorbent assay (ELISA) and compared with COMP,. The diagnostic significance of TTR alone and in combination for RA. Results Serum COMP,TTR levels in early RA group were significantly higher than those in other rheumatic groups and normal controls (P0.05), and 25 (OH) D levels in early RA group were significantly lower than those in other rheumatic groups and normal controls (P0.05). There was no significant difference between the three factors in other rheumatism group and normal control group (P0.05). COMP,TTR alone detection, TTR sensitivity was high, COMP specificity was stronger. The specificity of combined detection was higher than that of single factor detection. Conclusion Serum COMP,TTR can be used as a biological marker for early diagnosis of RA, and combined detection is better in early RA.
【作者单位】：承德医学院附属医院风湿免疫科;承德医学院附属医院血液科;
【基金】：河北省医学适用技术跟踪项目(编号:GL2014066) 河北省承德市科学技术研究与发展计划(编号:201422021)
【分类号】：R593.22

【相似文献】