不同剂量坎格列净治疗2型糖尿病疗效与安全性的Meta分析

发布时间：2018-12-27 21:09

【摘要】：目的:系统评价不同剂量坎格列净治疗2型糖尿病的疗效与安全性,以为临床提供循证参考。方法:计算机检索Pub Med、Cochrane图书馆、Clinical Trails.gov、相关期刊论文、万方数据库、中文科技期刊数据库,收集不同剂量坎格列净治疗2型糖尿病的随机对照试验(RCT),对符合纳入标准的研究进行资料提取,并采用Cochrane系统评价员手册5.1.0进行质量评价后,采用Rev Man 5.3统计软件进行Meta分析。结果:共纳入11项RCT,合计5 399例患者。Meta分析结果显示,给予坎格列净300 mg/d在糖化血红蛋白水平[MD=0.14,95%CI(0.09,0.19),P0.001]、空腹血糖水平[MD=0.40,95%CI(0.20,0.61),P0.001]和体质量降低率[MD=0.69,95%CI(0.42,0.96),P0.001]方面均显著优于100 mg/d剂量,差异均有统计学意义;两组患者总体不良反应发生率[RR=0.97,95%CI(0.94,1.01),P=0.10]、低血糖发生率[RR=1.02,95%CI(0.94,1.10),P=0.67]、尿路感染发生率[RR=0.96,95%CI(0.78,1.18),P=0.69]比较,差异均无统计学意义;试验患者的生殖道霉菌感染发生率显著高于对照组,差异有统计学意义[RR=0.84,95%CI(0.70,1.00),P=0.04]。结论:给予坎格列净300 mg/d相比于100 mg/d能更好地控制2型糖尿病患者的糖化血红蛋白、空腹血糖水平和体质量,但临床使用时应特别注意生殖道霉菌感染的发生。
[Abstract]:Objective: to evaluate the efficacy and safety of different doses of kangliejing in the treatment of type 2 diabetes mellitus, and to provide evidence-based reference for clinical practice. Methods: Pub Med,Cochrane Library, Clinical Trails.gov, full text Database of Chinese Journal, Wanfang Database, Chinese Science and Technology Journal Database were searched by computer. (RCT), was collected from randomized controlled trial of different doses of Canglicine in the treatment of type 2 diabetes mellitus. The data were extracted from the research according to the inclusion standard, and the Cochrane system evaluator's manual 5.1.0 was used to evaluate the quality, and the Meta analysis was carried out by Rev Man 5.3 statistical software. Results: a total of 5 399 patients with 11 items of RCT, were included. The results of Meta analysis showed that the level of glycosylated hemoglobin (MD=0.14,95%CI (0. 09 卤0. 19), P0. 001) was measured by Meta. Fasting blood glucose level [MD=0.40,95%CI (0.20 卤0.61), P0.001] and body mass reduction rate (MD=0.69,95%CI (0.42m0.96), P0.001) were significantly better than that of 100mg/d dose (P 0.001). The overall incidence of adverse reactions in both groups [RR=0.97,95%CI (0.94 卤1.01), P < 0.10], hypoglycemia [RR=1.02,95%CI (0.94 卤1.10), P > 0.67]. There was no significant difference in the incidence of urinary tract infection [RR=0.96,95%CI (0.78 卤1.18), P < 0.69]. The incidence of genital tract fungal infection in the patients was significantly higher than that in the control group (RR=0.84,95%CI (0.70 ~ 1.00), P ~ (0.04). Conclusion: the glycosylated hemoglobin, fasting blood glucose level and body mass of patients with type 2 diabetes mellitus can be better controlled by kangliejing 300 mg/d than that of 100 mg/d, but the occurrence of genital tract fungal infection should be paid special attention to in clinical use.
【作者单位】：北京大学药学院药事管理与临床药学系;北京大学第五临床医学院/北京医院;
【分类号】：R587.1

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