α-硫辛酸治疗老年糖尿病周围神经病变患者的疗效及作用机制

发布时间：2018-12-28 16:32

【摘要】：目的观察α-硫辛酸治疗老年糖尿病周围神经病变(DNP)的效果,并探究其作用机制。方法 92例老年DNP患者根据就诊顺序利用随机数字表分为常规组与联合组。联合组在常规治疗的基础上给予α-硫辛酸治疗。对比综合疗效、治疗前后正中、腓总神经的运动神经传导速度(MCV)和感觉神经传导速度(SCV),并观察治疗方案的安全性。结果组间综合疗效等级数据存在显著性差异(P0.05),且联合组总有效率(89.13%)显著高于常规组(63.04%,P0.05);治疗后两组正中神经及腓总神经MCV、SCV均较治疗前显著升高(P0.05),且治疗后联合组神经传导速度数据显著高于常规组(P0.05);两组不良反应发生率无显著差异(P0.05)。结论采用α-硫辛酸治疗老年DNP效果良好且安全性高,能显著改善神经传导速度,推测与抗氧化应激作用有关。
[Abstract]:Objective to observe the effect of 伪-lipoic acid on senile diabetic peripheral neuropathy (DNP) and explore its mechanism. Methods 92 elderly patients with DNP were randomly divided into routine group and combined group. The combined group was treated with 伪-lipoic acid on the basis of routine treatment. Compared with the comprehensive curative effect, the motor nerve conduction velocity (MCV) and sensory nerve conduction velocity (SCV),) of the common peroneal nerve before and after treatment were observed and the safety of the treatment was observed. Results there was significant difference between the two groups (P0.05), and the total effective rate of the combined group (89.13%) was significantly higher than that of the routine group (63.04g / kg, P0.05). After treatment, the MCV,SCV of median nerve and common peroneal nerve in both groups were significantly higher than that before treatment (P0.05), and the nerve conduction velocity data of combined group were significantly higher than that of routine group after treatment (P0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P0.05). Conclusion 伪-lipoic acid is effective and safe in the treatment of senile DNP, and it can significantly improve nerve conduction velocity, which may be related to the effect of antioxidant stress.
【作者单位】：四平市中心人民医院;吉林大学公共卫生学院;四平市第四人民医院心内科;
【分类号】：R587.2

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