富马酸二甲酯在人体自身免疫疾病中的临床应用进展

发布时间：2019-01-02 10:56

【摘要】：正1前言富马酸二甲酯(Dimethyl fumarate,DMF)是一类将富马酸酯化后再利用甲醇重结晶得到的酯化物,用途十分广泛。在食品领域,其被用作食品抑菌剂,用于食品的防腐和保鲜~([1])。20世纪50年代DMF开始应用于临床银屑病的治疗,随着银屑病免疫致病机制逐渐被揭示,DMF的免疫调节作用也被进一步深入研究~([2])。2013年DMF被FDA批准用于多发性硬化的治疗,近年来DMF在其他免疫相关性疾病
[Abstract]:Dimethyl fumarate (Dimethyl fumarate,DMF) is a kind of esterified compounds obtained by esterification of fumaric acid and recrystallization of methanol. In the field of food, it is used as a bacteriostatic agent for antiseptic and fresh-keeping of food. In 1950s, DMF was applied to the treatment of clinical psoriasis, and the mechanism of psoriasis immune pathogenesis was gradually revealed. The immunomodulatory effect of DMF has also been further studied. DMF was approved by FDA in 2013 for the treatment of multiple sclerosis, and DMF has been used in other immune-related diseases in recent years.
【作者单位】：第二军医大学长海医院烧伤外科全军烧伤研究所;
【基金】：国家自然科学基金国际(地区)合作与交流项目(81120108015) 国家973计划项目(2012CB518100) 十二五科技计划(AWS11J008,AWS14C001,201502028) 第二军医大学长海医院(CH125510200)重点学科建设计划项目资助
【分类号】：R593.2

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