多廿烷醇联合阿托伐他汀治疗对高脂血症患者高密度脂蛋白颗粒的影响

发布时间：2019-01-02 12:24

【摘要】：目的探讨多廿烷醇联合阿托伐他汀和单用阿托伐他汀治疗对高脂血症患者血脂水平及高密度脂蛋白(HDL)颗粒的影响。方法选择高脂血症患者49例,随机分为3组,分别为安慰剂对照组(n=17)、阿托伐他汀20 mg治疗组(n=16)和多廿烷醇20 mg联合阿托伐他汀20 mg治疗组(n=16,联合治疗组)。Lipoprint脂蛋白分类检测仪对HDL颗粒进行分类。治疗8周后比较3组治疗前后血脂指标及HDL颗粒的变化,分析多廿烷醇联合阿托伐他汀和单用阿托伐他汀治疗对HDL颗粒的影响。结果与治疗前比较,治疗后阿托伐他汀组和联合治疗组的甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDLC)浓度均降低(P0.05,P0.001),而高密度脂蛋白胆固醇(HDLC)浓度的差异均无统计学意义(P0.05)。经阿托伐他汀治疗后,大颗粒HDLC浓度及百分比均显著升高(P0.05),而小颗粒HDLC浓度及百分比均显著降低(P0.05)。在联合治疗组,大颗粒HDLC浓度及百分比明显增加(P0.05),小颗粒HDLC浓度及百分比均明显降低(P0.001)。联合治疗组小颗粒HDL浓度和百分比的降低值显著大于阿托伐他汀组。结论阿托伐他汀组和联合治疗组均显著改善高脂血症患者的HDL颗粒分布,增加大颗粒HDLC浓度及百分比,同时降低小颗粒HDLC的浓度及百分比;多廿烷醇联合阿托伐他汀降低小颗粒HDLC浓度与百分比的效果明显优于阿托伐他汀单独治疗组。
[Abstract]:Objective to investigate the effects of polyicosanol combined with Atto vastatin and Atto vastatin alone on blood lipids and high density lipoprotein (HDL) granules in hyperlipidemia patients. Methods 49 patients with hyperlipidemia were randomly divided into three groups: placebo control group (n = 17), Atto vastatin 20 mg group (n = 16) and polyicosanol 20 mg combined with Atto vastatin 20 mg treatment group (n = 16). HDL granules were classified by). Lipoprint lipoprotein classifier in combined treatment group. After 8 weeks of treatment, the changes of serum lipids and HDL granules in three groups were compared before and after treatment, and the effects of polyicosanol combined with Atto vastatin and Atto vastatin alone on HDL granules were analyzed. Results compared with before treatment, the concentration of triglyceride (TG), total cholesterol (TC), low density lipoprotein cholesterol (LDLC) in Atto vastatin group and combined treatment group decreased after treatment (P0. 05% P0. 001). There was no significant difference in (HDLC) concentration of high density lipoprotein cholesterol (P0.05). After treatment with Atto vastatin, the concentration and percentage of HDLC in large particles increased significantly (P0.05), while the concentration and percentage of HDLC in small particles decreased significantly (P0.05). In the combined treatment group, the concentration and percentage of HDLC in large granules increased significantly (P0.05), while the concentration and percentage of HDLC in small particles decreased significantly (P0.001). The decrease of HDL concentration and percentage of small particles in the combined treatment group was significantly higher than that in the Atto vastatin group. Conclusion both Atto vastatin group and combined treatment group can significantly improve the distribution of HDL granules in hyperlipidemia patients, increase the concentration and percentage of HDLC in large particles, and decrease the concentration and percentage of HDLC in small particles. The effect of polyicosanol combined with Atto vastatin in reducing the concentration and percentage of HDLC in small particles was significantly better than that in Atto vastatin alone group.
【作者单位】：中国医学科学院国家心血管病中心阜外医院血脂异常与心血管病诊治中心;
【分类号】：R542.2

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