脑梗死合并亚临床甲状腺功能减退与内脂素及内皮素的关系

发布时间：2019-01-05 08:16

【摘要】：目的脑梗死患者中关于亚临床甲状腺功能和内脂素、内皮素关系的研究较少。文中旨在探讨脑梗死合并亚临床甲状腺功能减退(简称甲减)患者甲状腺功能与内脂素、内皮素的关系。方法入选2011年1月至2017年7月海南医学院第二附属医院内分泌科及老年病科脑梗死患者200例。将其分为4组:对照组[脑梗死合并甲状腺功能正常,促甲状腺激素(TSH)、游离甲状腺素(FT4)、游离三碘甲状腺原氨酸(FT3)均正常,n=40]、轻度亚临床甲减组(4≤TSH10 m IU/L,FT3、FT4正常,n=60)、重度亚临床甲减组(TSH≥10 m IU/L,FT3、FT4正常,n=60)、临床甲减组(TSH≥4 m IU/L,FT3、FT4降低,n=40)。其中轻度亚临床甲减组随机分为轻度服药亚组、轻度未服药亚组;重度亚临床甲减组患者随机分为重度服药亚组、重度未服药亚组,每组30例。2个服药组在常规治疗基础上加用左甲状腺素片;2个未服药组采用常规治疗。记录所有患者年龄、性别、BMI、血压、血糖、血脂、甲状腺功能等,比较患者内脂素、内皮素的差异。结果重度亚临床甲减组、临床甲减组内脂素含量[(46.3±10.1)、(49.5±13.6)ng/m L]较对照组[(40.2±9.7)ng/m L]明显升高(P0.05)。重度服药亚组6个月时内脂素较重度未服药亚组升高[(42.9±6.4)ng/m L vs(39.3±5.5)ng/m L,P0.05]。结论相对于甲状腺功能正常的脑梗死患者,重度亚临床甲减合并脑梗死患者与内脂素关系更密切。对脑梗死患者应积极筛查甲状腺功能,及早发现和干预重度亚临床甲减非常必要。
[Abstract]:Objective to study the relationship between subclinical thyroid function and endothelin in patients with cerebral infarction. The purpose of this study was to investigate the relationship between thyroid function and endothelin (et) in patients with subclinical hypothyroidism (hypothyroidism) after cerebral infarction. Methods from January 2011 to July 2017, 200 patients with cerebral infarction in Department of Endocrinology and Department of Geriatrics, second affiliated Hospital of Hainan Medical College were selected. It was divided into four groups: control group [cerebral infarction with normal thyroid function, thyroid stimulating hormone (TSH), free thyroxine (FT4), free triiodothyronine (FT3) were normal, nm40]. Mild subclinical hypothyroidism (4 鈮，

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