钙网织蛋白在类风湿关节炎早期诊断及活动度评估中的作用

发布时间：2019-01-10 18:17

【摘要】：目的探讨钙网织蛋白(CRT)在类风湿关节炎(RA)早期诊断和疾病活动度评估中的作用及临床意义。方法收集45例早期活动性RA患者、35例骨性关节炎(OA)患者,以及30例正常对照者(HC)的血清标本。采用酶联免疫吸附法检测3组患者血清CRT水平,魏氏法检测红细胞沉降率(ESR),免疫散射比浊法检测C反应蛋白(CRP)的水平。采用Spearman对血清CRT水平与疾病活动度评分(DAS28)、ESR、CRP进行相关性分析。结果 RA组血清CRT水平[(6.7±2.5)μg/L]高于OA组[(3.9±0.9)μg/L]和HC组[(3.8±0.7)μg/L](P0.05),OA组与HC组的血清CRT水平比较,差异无统计学意义(P0.05);与OA组和HC组比较,RA组ESR、CRP水平升高(P0.05);RA组血清CRT水平与DAS28评分、ESR及CRP呈正相关(rs=0.391、0.459和0.454,P=0.008、0.002和0.002)。结论早期活动性RA患者血清CRT水平增高,CRT与DAS28评分、ESR及CRP呈正相关,提示CRT可能成为早期诊断RA,以及辅助ESR、CRP评估RA疾病活动度的潜在血清学指标。
[Abstract]:Objective to investigate the role and clinical significance of calmodulin (CRT) in the early diagnosis and disease activity evaluation of rheumatoid arthritis (RA). Methods Serum samples of 45 patients with early active RA, 35 patients with (OA) of osteoarthritis and 30 normal controls were collected. The serum CRT level was detected by enzyme linked immunosorbent assay (Elisa), and the level of C-reactive protein (CRP) (CRP) was detected by (ESR), immunoturbidimetry. The correlation between serum CRT level and disease activity score (DAS28) and ESR,CRP was analyzed by Spearman. Results the serum CRT level in RA group [(6.7 卤2.5) 渭 g / L] was higher than that in OA group [(3.9 卤0.9) 渭 g / L] and HC group [(3.8 卤0.7) 渭 g / L] (P0.05). The difference was not statistically significant (P0.05). Compared with OA group and HC group, the level of ESR,CRP in RA group was higher (P0.05). The level of serum CRT in); RA group was positively correlated with DAS28 score, ESR and CRP (rs=0.391,0.459 and 0.454P0. 008 卤0. 002 and 0.002). Conclusion the level of serum CRT in patients with early active RA is increased, and CRT is positively correlated with DAS28 score, ESR and CRP. It suggests that CRT may be a potential serological marker for early diagnosis of RA, and assistant ESR,CRP for evaluating RA disease activity.
【作者单位】：河北省唐山市第二医院;天津医科大学医学检验学院;天津医科大学总医院风湿免疫科;
【基金】：河北省科技计划项目(No:152777157)
【分类号】：R593.22

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