FRAX、BMD与昆明地区女性骨质疏松性骨折的相关研究

发布时间：2019-01-28 10:58

【摘要】：目的：探讨BMD对骨质疏松性骨折的预测及FRAX有或无BMD情况下哪种方法能更好预测骨质疏松性骨折。方法：对2012年在昆明医科大学第一附属医院体检的1000例在昆明长期居住(10年)、年龄40-90岁,行DXA检测股骨颈、大粗隆、全髋或L1、L2、L3、L4、L1-L4骨密度的女性人群,进行两年后的电话回访。共计回访有效人数869例,失访人数131人。将此869例人群划分为骨量正常、骨量减少、骨质疏松三组。骨量减少人群中,测股骨颈BMD的为F组,测腰椎BMD的为NF组,分析比较F组及NF组人群的相关性。结果：在218例F组的人群中有骨折患者的股骨颈BMD、大粗隆BMD、全髋部BMD均较无骨折的患者低(P0.05),差异有统计学意义。FRAX使用BMD计算出髋部骨折概率及主要骨松性骨折概率分别为(2.981±3.360)及(7.169±4.684),高于未使用BMD计算的骨折概率(P0.01)。F组的218例女性中FRAX为高风险的骨折概率(13.9%)大于NF组的215例女性中FRAX为高风险的骨折概率(0%),卡方值为0.244,P0.05。每日日晒时间和运动时间与FRAX计算主要骨质疏松骨折概率无相关性(P0.05),与髋部骨折概率呈负相关(P0.001)；服用维生素D与FRAX计算主要骨质疏松骨折概率和10年髋部骨折概率均成负相关(P0.001)。结论：BMD和FRAX均可预测骨质疏松性骨折的风险；FRAX在输入BMD的情况下较不输入BMD能够更好的预测骨折。
[Abstract]:Objective: to study the prediction of osteoporotic fracture by BMD and the method of FRAX with or without BMD. Methods: 1000 patients (aged 40-90 years old) who were examined in the first affiliated Hospital of Kunming Medical University in 2012 were examined by DXA for femoral neck, trochanter, total hip or L1, L2, L3, L4. Women with L1-L4 bone density were interviewed by telephone two years later. A total of 869 cases were returned and 131 were lost. The 869 cases were divided into three groups: normal bone mass, decreased bone mass and osteoporosis. In the population with decreased bone mass, the BMD of femoral neck was measured in group F and the group of lumbar BMD was NF. The correlation between group F and group NF was analyzed and compared. Results: the total BMD of femoral neck BMD, trochanter BMD, in 218 patients with fracture in group F was lower than that in patients without fracture (P0.05). FRAX used BMD to calculate the probability of hip fracture and the probability of main bone loose fracture were (2.981 卤3.360) and (7.169 卤4.684), respectively. The probability of fracture with high risk of FRAX was higher (13.9%) than that of 215 women without BMD (P0.01). F group, P 0.01). F group, 0%). The chi-square value was 0.244, higher than that of FRAX group (0%). P0.05. There was no correlation between daily sunshine time and exercise time and the probability of main osteoporotic fracture calculated by FRAX (P0.05), but there was a negative correlation with hip fracture probability (P0. 001). There was a negative correlation between vitamin D intake and the probability of main osteoporotic fracture and 10 years hip fracture calculated by FRAX (P0. 001). Conclusion: both BMD and FRAX can predict the risk of osteoporotic fracture and FRAX can predict the fracture better than that without BMD.
【学位授予单位】：昆明医科大学
【学位级别】：硕士
【学位授予年份】：2015
【分类号】：R580

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