高尿酸血症患者血清胱抑素C与肾小球滤过率的相关性研究
发布时间:2019-01-28 11:49
【摘要】:目的通过检测高尿酸血症(HUA)患者血清胱抑素-C(Cys-C)水平与GFR的相关性,探讨其在HUA性肾损伤早期诊断中的价值。方法 选取无症状HUA患者(sHUA)60例、痛风(Gout)患者50例和正常对照组(NC)60名。改良MDRD公式计算eGFR,并测定各组血清Cys-C、β2微球蛋白(β2-MG)、Scr、SUA、TG、高敏C反应蛋白(hsC-RP)等生化指标。分析血清Cys-C、β2-MG与eGFR、Scr等指标的关系。结果 Gout组血清Cys-C、β2-MG、Scr、SUA、hsC-RP、TG、BMI高于NC组(P0.05或P0.01),eGFR、HDL-C低于NC组(P0.05),Cys-C、hsC-RP、BMI、β_2-MG高于sHUA组(P0.05)。sHUA组Cys-C、SUA、TG高于NC组,HDL-C低于NC组。血清Cys-C与eGFR呈负相关(r=-0.457,P=0.003),与Scr、年龄、SUA呈正相关(r=0.472、0.325、0.171,P=0.000、0.001、0.05)。多元线性回归分析显示,eGFR、Scr、SUA、年龄是血清Cys-C水平升高的危险因素。结论血清Cys-C能反映GFR的变化,是HUA性肾损伤早期诊断的良好血清标志物。
[Abstract]:Objective to investigate the correlation between serum cystatin C (Cys-C) and GFR in patients with hyperuricemia (HUA) and to explore its value in early diagnosis of HUA renal injury. Methods 60 patients with asymptomatic HUA (sHUA), 50 patients with gout (Gout) and 60 normal controls were selected. The serum Cys-C, 尾 2 microglobulin (尾 2-MG) and Scr,SUA,TG, Gao Min C reactive protein (hsC-RP) were calculated by modified MDRD formula. The relationship between serum Cys-C, 尾 2-MG and eGFR,Scr was analyzed. Results in Gout group, the serum Cys-C, 尾 2-MGG-ScrSG-SUAHS-C-RPGN was higher than that of NC group (P0.05 or P0.01), eGFR,HDL-C was lower than that of NC group (P0.05), Cys-C,hsC-RP,BMI, was higher than that of NC group (P0.05). 尾 _ 2-MG was higher than sHUA group (P0.05) Cys-C,SUA,TG in). SHUA group was higher than that in NC group, HDL-C was lower than NC group. There was a negative correlation between serum Cys-C and eGFR (r = -0.457), and a positive correlation between serum Cys-C and Scr, age and SUA (r = 0.472 ~ 0.325 ~ 0.171 ~ 0.0000.000 / 0. 05). Multiple linear regression analysis showed that the age of eGFR,Scr,SUA, was a risk factor for the increase of serum Cys-C level. Conclusion Serum Cys-C can reflect the changes of GFR and is a good serum marker for early diagnosis of HUA renal injury.
【作者单位】: 南方医科大学研究生学院;解放军第305医院内分泌科;
【分类号】:R589.7
[Abstract]:Objective to investigate the correlation between serum cystatin C (Cys-C) and GFR in patients with hyperuricemia (HUA) and to explore its value in early diagnosis of HUA renal injury. Methods 60 patients with asymptomatic HUA (sHUA), 50 patients with gout (Gout) and 60 normal controls were selected. The serum Cys-C, 尾 2 microglobulin (尾 2-MG) and Scr,SUA,TG, Gao Min C reactive protein (hsC-RP) were calculated by modified MDRD formula. The relationship between serum Cys-C, 尾 2-MG and eGFR,Scr was analyzed. Results in Gout group, the serum Cys-C, 尾 2-MGG-ScrSG-SUAHS-C-RPGN was higher than that of NC group (P0.05 or P0.01), eGFR,HDL-C was lower than that of NC group (P0.05), Cys-C,hsC-RP,BMI, was higher than that of NC group (P0.05). 尾 _ 2-MG was higher than sHUA group (P0.05) Cys-C,SUA,TG in). SHUA group was higher than that in NC group, HDL-C was lower than NC group. There was a negative correlation between serum Cys-C and eGFR (r = -0.457), and a positive correlation between serum Cys-C and Scr, age and SUA (r = 0.472 ~ 0.325 ~ 0.171 ~ 0.0000.000 / 0. 05). Multiple linear regression analysis showed that the age of eGFR,Scr,SUA, was a risk factor for the increase of serum Cys-C level. Conclusion Serum Cys-C can reflect the changes of GFR and is a good serum marker for early diagnosis of HUA renal injury.
【作者单位】: 南方医科大学研究生学院;解放军第305医院内分泌科;
【分类号】:R589.7
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