SLC2A9基因和SLC22A12基因与高尿酸血症关联性研究

发布时间：2019-01-30 09:46

【摘要】：目的探讨宁夏地区人群SLC2A9基因单核苷酸多态性rs2241480、SLC22A12基因单核苷酸多态性rs559946位点与高尿酸血症患病的关联性。方法采用1:1匹配的方法筛选体检机构确诊的高尿酸血症的患者和无血缘关系的健康人群各368例,收集研究对象的空腹静脉血5ml,采用Sequenom Mass ARRAY iPLEX GOLD技术对SLC2A9基因rs2241480、SLC22A12基因rs559946位点进行检测分析。结果 SLC2A9基因rs2241480病例组和对照组在不同基因型上血尿酸水平差异有统计学意义(X~2=6.000,P0.050),SLC22A12基因rs559946位点病例组和对照组在不同基因型上血尿酸水平差异无统计学意义(X~2=5.700,P0.050),应用多因子降维法(MDR),进行基因-基因交互作用结果显示:SLC2A9基因rs2241480位点与SLC22A12基因rs559946位点具有拮抗作用(P0.005),BMI、TG、Cr、可能为高尿酸血症的影响因素(P0.05)。结论 SLC2A9基因rs2241480位点多态性与宁夏地区人群高尿酸血症具有相关性。
[Abstract]:Objective to investigate the association of SLC2A9 gene single nucleotide polymorphism (SLC2A9) single nucleotide polymorphism (rs2241480,SLC22A12) polymorphism rs559946 locus with hyperuricemia in Ningxia population. Methods the 1:1 matching method was used to screen 368 patients with hyperuricemia diagnosed by physical examination and 368 healthy people without blood relationship. The fasting venous blood of the subjects was collected at 5ml, and the rs2241480, of SLC2A9 gene was detected by Sequenom Mass ARRAY iPLEX GOLD technique. The rs559946 locus of SLC22A12 gene was detected and analyzed. Results the levels of uric acid in patients with SLC2A9 gene rs2241480 were significantly different from those in control group (XP0.050). There was no significant difference in serum uric acid levels between patients with rs559946 locus of SLC22A12 gene and control group in different genotypes (XP0. 050). (MDR), was reduced by multivariate dimensionality reduction method. The results of gene-gene interaction showed that rs2241480 site of SLC2A9 gene and rs559946 site of SLC22A12 gene had antagonistic effect (P0.005), BMI,TG,Cr, might be the influencing factor of hyperuricemia (P0.05). Conclusion rs2241480 polymorphism of SLC2A9 gene is associated with hyperuricemia in Ningxia population.
【作者单位】：宁夏医科大学公共卫生学院流行病与卫生统计学系;
【基金】：宁夏高等学校科学技术研究项目(NGY2014087)
【分类号】：R589.7

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