克罗米芬联合二甲双胍对多囊卵巢综合征患者外周血T细胞亚群及氧化应激水平的影响

发布时间：2019-02-14 21:18

【摘要】：目的探讨克罗米芬联合二甲双胍对多囊卵巢综合征(PCOS)患者外周血T细胞亚群及氧化应激水平的影响。方法选择PCOS患者80例,随机分为观察组和对照组各40例。两组均口服克罗米芬,观察组在此基础上联合二甲双胍,均连续治疗3个月经周期。比较两组治疗前后空腹血糖(GLU)、餐后2 h血糖(2 h PG)、糖化血红蛋白(Hb A1C)、胰岛素抵抗指数(HOMA-IR),血清谷胱甘肽过氧化物酶(GSH-PX)、超氧化物歧化酶(SOD)、丙二醛(MDA)及晚期氧化蛋白产物(AOPP),CD8~+、CD4~+细胞百分比及CD8~+/CD4~+。结果两组治疗后GLU、2 h PG、Hb A1C、HOMA-IR水平均较治疗前降低,且观察组均低于对照组(P均0.05)。与治疗前比较,两组治疗后血清MDA、AOPP水平均降低,血清GSH-PX、SOD水平均升高,且观察组变化均较对照组更显著(P均0.05)。与对照组治疗后及同组治疗前比较,观察组治疗后CD4~+细胞百分比降低、CD8~+细胞百分比升高、CD4~+/CD8~+降低(P均0.05),对照组治疗前后CD4~+、CD8~+细胞百分比及CD4~+/CD8~+比较差异均无统计学意义(P均0.05)。结论与单用克罗米芬比较,克罗米芬联合二甲双胍治疗PCOS有助于改善患者胰岛素抵抗、纠正T细胞亚群结构失调、降低氧化应激水平。
[Abstract]:Objective to investigate the effects of clomiphene combined with metformin on T cell subsets and oxidative stress in peripheral blood of patients with polycystic ovary syndrome (PCOS). Methods Eighty patients with PCOS were randomly divided into two groups: the observation group (n = 40) and the control group (n = 40). Clomiphene was given orally in both groups, and the observation group combined with metformin for 3 consecutive menstrual cycles. Serum glutathione peroxidase (GSH-PX), insulin resistance index (HOMA-IR) and fasting blood glucose (2 h PG), glycosylated hemoglobin (Hb A1C), insulin resistance index (HOMA-IR) were compared between the two groups before and after treatment. Percentage of superoxide dismutase (SOD) (SOD), malondialdehyde (MDA) and late oxidative protein products (AOPP), CD8~, CD4~) and CD8~ / CD4~. Results after treatment, the levels of GLU,2 h PG,Hb A 1 Con HOMA-IR in the observation group were lower than those in the control group (P 0. 05). Compared with before treatment, the serum MDA,AOPP level decreased and the serum GSH-PX,SOD level increased after treatment in both groups, and the changes in the observation group were more significant than those in the control group (P 0.05). Compared with the control group and the control group before and after treatment, the percentage of CD4~ cells decreased, the percentage of CD8~ cells increased, and the CD4~ / CD8~ ratio decreased after treatment in the observation group, and CD4~ in the control group before and after treatment. There was no significant difference in the percentage of CD8~ cells and CD4~ / CD8~ (P < 0. 05). Conclusion compared with clomiphene alone, clomiphene combined with metformin can improve insulin resistance, correct the disorder of T cell subsets and reduce oxidative stress in patients with PCOS.
【作者单位】：青海省妇女儿童医院;
【分类号】：R711.75

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