结合珠蛋白基因多态性与糖尿病血管并发症的研究进展
发布时间：2019-02-14 23:14
【摘要】：结合珠蛋白(Hp)又称血红素结合蛋白、触珠蛋白,是肝脏合成的一种急性时相反应蛋白。Hp可以与游离血红蛋白(Hb)结合形成Hp-Hb复合物,通过巨噬细胞清道夫受体CD163介导的内吞作用进行降解,从而阻断血红蛋白诱导的氧化损伤。人类Hp有Hp1-1、Hp2-1、Hp2-2共3种基因型。研究显示,不同Hp基因型对糖尿病患者血管并发症的影响不尽相同。本文就Hp基因多态性与糖尿病血管并发症的相关研究作一综述。
[Abstract]:Globin (Hp), also known as heme binding protein, is an acute phase reactive protein synthesized by the liver. Hp binds to free hemoglobin (Hb) to form Hp-Hb complex. The degradation of macrophage scavenger receptor CD163 mediated endocytosis was used to block the oxidative damage induced by hemoglobin. Human Hp has three genotypes of Hp1-1,Hp2-1,Hp2-2. Studies have shown that different Hp genotypes have different effects on vascular complications in diabetic patients. This article reviews the relationship between Hp gene polymorphism and diabetic vascular complications.
【作者单位】： 中南大学湘雅三医院;
【分类号】：R587.2
[Abstract]:Globin (Hp), also known as heme binding protein, is an acute phase reactive protein synthesized by the liver. Hp binds to free hemoglobin (Hb) to form Hp-Hb complex. The degradation of macrophage scavenger receptor CD163 mediated endocytosis was used to block the oxidative damage induced by hemoglobin. Human Hp has three genotypes of Hp1-1,Hp2-1,Hp2-2. Studies have shown that different Hp genotypes have different effects on vascular complications in diabetic patients. This article reviews the relationship between Hp gene polymorphism and diabetic vascular complications.
【作者单位】： 中南大学湘雅三医院;
【分类号】：R587.2
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