山东沿海地区成年女性骨密度调查及骨量分析

发布时间：2019-02-15 22:06

【摘要】：目的确立山东沿海地区成年女性骨密度(bone mineral density,BMD)的正常参考范围,建立诊断成年女性骨质疏松(osteoporosis,OP)的多骨骼部位BMD参考值,并考察其应用。方法测量25~35岁健康成年女性的BMD值,交叉校正烟台Lunar i型与青岛Lunar NT型双能X射线骨密度仪(dual energy X-ray absorptiometry,DXA),得到腰椎(L2~4)正位和左侧髋部(股骨颈、大转子、Ward's三角区)6个骨骼区域的线性回归方程,并矫正烟台、青岛两地的BMD数据;比较烟台、青岛两地区校正后的BMD值,找出最佳拟合的方程,建立山东沿海地区正常成年女性的BMD数据库;利用该数据库检测当地中老年女性OP的发病率,同时比较新建的数据库与仪器自备数据库的适用性。结果 (1)烟台Lunar i型与青岛Lunar NT型DXA测得的BMD值存在明显的线性关系。(2)6个骨骼区域BMD随年龄的变化,用3次回归模型模拟得到山东沿海地区正常成年女性的BMD数据库,结果显示BMD峰值骨量在20~40岁,从40岁之后开始直线下降。(3)通过本文建立的BMD数据库,考察当地2005-2012年体检的女性(50~89岁)发现,山东沿海地区中老年女性OP发病率随年龄逐年增加,但低于其他地区OP发病率。与Lunar i型DXA自身配备的数据库相比,本研究建立的数据库比Lunar i型DXA自配数据库检出的OP发病率高。结论本研究建立的参考数据库适用于山东沿海地区,可作为当地诊断OP的依据。
[Abstract]:Objective to establish the normal reference range of bone mineral density (bone mineral density,BMD) of adult women in coastal areas of Shandong Province, and to establish the reference value of BMD for the diagnosis of adult female osteoporosis (osteoporosis,OP), and to investigate its application. Methods the BMD values of healthy adult women aged 25 to 35 years were measured. The cross-corrected Lunar I and Qingdao Lunar NT dual energy X-ray absorptiometry (dual energy X-ray absorptiometry,DXA) were used to obtain the positive position of lumbar vertebrae (L2F4) and the left hip (femoral neck, greater trochanter). Linear regression equation of 6 bone regions in Ward's triangle, and BMD data of Yantai and Qingdao were corrected. The corrected BMD values in Yantai and Qingdao were compared and the best fitting equation was found. The BMD database of normal adult women in Shandong coastal areas was established. This database was used to detect the incidence of OP in middle-aged and elderly women, and to compare the applicability of the newly built database and the instrument database. Results (1) there was a significant linear relationship between BMD values measured by Yantai Lunar I type and Qingdao Lunar NT type DXA. (2) BMD in 6 skeletal regions varied with age. Three times regression model was used to simulate the BMD database of normal adult women in Shandong coastal area. The results showed that the peak bone mass of BMD declined linearly from 20 to 40 years old. (3) the BMD database was established in this paper. The incidence of OP among middle-aged and elderly women in coastal areas of Shandong Province increased year by year, but lower than that of other regions, according to the investigation of women (50 ~ 89 years old) who were examined from 2005 to 2012. Compared with the database equipped with Lunar I type DXA, the database established in this study is higher than that of Lunar I type DXA database which detects the incidence of OP. Conclusion the reference database established in this study is applicable to the coastal areas of Shandong Province and can be used as a basis for local diagnosis of OP.
【作者单位】：烟台毓璜顶医院内分泌科;烟台毓璜顶医院放射科;青岛大学附属医院内分泌科;
【基金】：山东省医药卫生科技发展计划项目(2013ws0037)
【分类号】：R580

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