忍冬藤痛风颗粒联合西药治疗湿热蕴结型痛风性关节炎的临床观察
发布时间：2019-03-01 07:59
【摘要】：目的探讨自拟经验方忍冬藤痛风颗粒联合西药治疗湿热蕴结型痛风性关节炎的临床疗效,为临床诊治痛风性关节炎提供有效的治疗。方法选取90例湿热蕴结型痛风性关节炎患者为研究对象,采用随机数字表法分为对照组与治疗组,对照组45例患者采用口服秋水仙碱片,发作时首次服1mg,1h后再服用0.5mg,12h后改为2次/d,共服用1周;同时服用别嘌呤醇片,0.1g/次,3次/d,疗程为2周。治疗组45例患者在对照组西药治疗的基础上加用自拟经验方忍冬藤痛风颗粒进行治疗,两组疗程均为2周。记录中医证候积分、VAS评分、ESR、CRP及UA 6项指标;进而比较两组患者治疗前、治疗后第1周、治疗后第2周与治疗前及两组间治疗效果的差异。结果治疗组总有效率为95.12%,而对照组总有效率为80.00%,两组间比较差异有统计学意义(P0.05);两组患者治疗后中医证候积分、VAS评分、ESR、CRP及UA6项指标较治疗前有明显改善,差异均有统计学意义(P0.05)。治疗组治疗后较对照组治疗后指标改善更加显著,差异有统计学意义(P0.05)。结论忍冬藤痛风颗粒联合西药更加有效地控制痛风性关节炎的症状,减轻患者的疼痛,能够降低血沉(ESR)、C反应蛋白(CRP)、血尿酸(UA)的水平,临床疗效优于单纯西药治疗,值得临床推广运用。
[Abstract]:Objective to explore the clinical efficacy of the self-made prescription of honeysuckle gout granule combined with western medicine in the treatment of gouty arthritis of damp-heat accumulation type in order to provide effective treatment for clinical diagnosis and treatment of gouty arthritis. Methods 90 patients with gouty arthritis of dampness-heat accumulation type were randomly divided into two groups: control group (n = 45) and treatment group (n = 45). The control group (n = 45) took colchicine tablets orally for the first time and took them 1 mg at the time of onset, and then took 0.5 mg (n = 1) after 1 hour. After 12 hours, it was changed to 2 times per day for a total of 1 week. At the same time, allopurinol tablets, 0.1g/, 3 times a day, the course of treatment for 2 weeks. Forty-five patients in the treatment group were treated with a self-made prescription of honeysuckle gout granule on the basis of western medicine treatment in the control group. The course of treatment in both groups was 2 weeks. Six indexes of TCM syndrome score, VAS score, ESR,CRP and UA were recorded, and the difference of therapeutic effect between the two groups was compared before treatment, 1 week after treatment, 2 weeks after treatment and before treatment and between the two groups. Results the total effective rate was 95.12% in the treatment group and 80.00% in the control group. There was significant difference between the two groups (P0.05). After treatment, the TCM syndrome score, VAS score, ESR,CRP and UA6 indexes of the two groups were significantly improved compared with those before treatment, the difference was statistically significant (P0.05). After treatment, the indexes of the treatment group were improved more significantly than that of the control group, the difference was statistically significant (P0.05). Conclusion Kindongteng gout granule combined with western medicine can effectively control the symptoms of gouty arthritis and relieve the pain of the patients. It can reduce the level of serum uric acid (UA) in erythrocyte sedimentation rate (ESR), C reactive protein (CRP),) and serum uric acid. The clinical curative effect is superior to the simple western medicine treatment, it is worth clinical popularization and application.
【作者单位】： 甘肃省中医院;甘肃中医药研究院;甘肃中医药大学;
【基金】：西北地区骨伤特色药物疗法重点研究项目 甘肃省兰州市人才创新创业项目(2015-RC-23) 甘肃陇中骨伤学术流派传承项目 甘肃省兰州市科技发展计划项目(2013-4-86)
【分类号】：R589.7
[Abstract]:Objective to explore the clinical efficacy of the self-made prescription of honeysuckle gout granule combined with western medicine in the treatment of gouty arthritis of damp-heat accumulation type in order to provide effective treatment for clinical diagnosis and treatment of gouty arthritis. Methods 90 patients with gouty arthritis of dampness-heat accumulation type were randomly divided into two groups: control group (n = 45) and treatment group (n = 45). The control group (n = 45) took colchicine tablets orally for the first time and took them 1 mg at the time of onset, and then took 0.5 mg (n = 1) after 1 hour. After 12 hours, it was changed to 2 times per day for a total of 1 week. At the same time, allopurinol tablets, 0.1g/, 3 times a day, the course of treatment for 2 weeks. Forty-five patients in the treatment group were treated with a self-made prescription of honeysuckle gout granule on the basis of western medicine treatment in the control group. The course of treatment in both groups was 2 weeks. Six indexes of TCM syndrome score, VAS score, ESR,CRP and UA were recorded, and the difference of therapeutic effect between the two groups was compared before treatment, 1 week after treatment, 2 weeks after treatment and before treatment and between the two groups. Results the total effective rate was 95.12% in the treatment group and 80.00% in the control group. There was significant difference between the two groups (P0.05). After treatment, the TCM syndrome score, VAS score, ESR,CRP and UA6 indexes of the two groups were significantly improved compared with those before treatment, the difference was statistically significant (P0.05). After treatment, the indexes of the treatment group were improved more significantly than that of the control group, the difference was statistically significant (P0.05). Conclusion Kindongteng gout granule combined with western medicine can effectively control the symptoms of gouty arthritis and relieve the pain of the patients. It can reduce the level of serum uric acid (UA) in erythrocyte sedimentation rate (ESR), C reactive protein (CRP),) and serum uric acid. The clinical curative effect is superior to the simple western medicine treatment, it is worth clinical popularization and application.
【作者单位】： 甘肃省中医院;甘肃中医药研究院;甘肃中医药大学;
【基金】：西北地区骨伤特色药物疗法重点研究项目 甘肃省兰州市人才创新创业项目(2015-RC-23) 甘肃陇中骨伤学术流派传承项目 甘肃省兰州市科技发展计划项目(2013-4-86)
【分类号】：R589.7
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1 丁林宝;高志欣;王s，
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