非布司他对慢性痛风性关节炎中NALP3炎性体的作用及意义
发布时间：2019-03-04 21:43
【摘要】：目的探讨非布司他治疗慢性痛风性关节炎及其对NALP3炎性体的影响。方法选取89例慢性痛风性关节炎患者和50例健康体检者,检测各组治疗前后NALP3炎性体mRNA及NALP3炎性体的蛋白表达水平。结果治疗组治疗前血尿酸、NALP3、ASC及Caspase-1 mRNA的表达较对照组高(P0.05)。苯溴马隆与别嘌醇组治疗前后NALP3炎性体无改变。非布司他组治疗后血尿酸、NALP3 mRNA(P=0.040)和Caspase-1 mRNA(P=0.023)的表达明显降低(P0.05),ASC mRNA的表达升高(P=0.043)。非布司他组治疗前后比较差异有统计学意义。结论 NALP3炎性体与慢性痛风性关节炎相关,非布司他可以更好的降尿酸并影响其功能。
[Abstract]:Objective to investigate the effect of non-bustane on chronic gouty arthritis and NALP3 inflammation. Methods 89 patients with chronic gouty arthritis and 50 healthy controls were selected to detect the protein expression of mRNA and NALP3 in NALP3 inflammation body before and after treatment. Results the expression of serum uric acid, NALP3,ASC and Caspase-1 mRNA in the treatment group before treatment was higher than that in the control group (P0.05). There was no change in the inflammatory body of NALP3 before and after treatment in the groups of benzimarone and allopurinol. The expression of serum uric acid, NALP3 mRNA (P < 0. 040) and Caspase-1 mRNA (P < 0. 023) were significantly decreased in non-bustane group after treatment (P < 0. 05). The expression of), ASC mRNA was increased (P < 0. 043). There was significant difference between before and after treatment in non-bustane group. Conclusion NALP3 is associated with chronic gouty arthritis, and non-bustane can reduce uric acid and affect its function.
【作者单位】： 广州医科大学附属第三医院荔湾医院风湿科;广东省医学科学院 广东省人民医院风湿科;
【基金】：广东省科技厅科研基金项目(编号:2016ZC0151)
【分类号】：R589.7
[Abstract]:Objective to investigate the effect of non-bustane on chronic gouty arthritis and NALP3 inflammation. Methods 89 patients with chronic gouty arthritis and 50 healthy controls were selected to detect the protein expression of mRNA and NALP3 in NALP3 inflammation body before and after treatment. Results the expression of serum uric acid, NALP3,ASC and Caspase-1 mRNA in the treatment group before treatment was higher than that in the control group (P0.05). There was no change in the inflammatory body of NALP3 before and after treatment in the groups of benzimarone and allopurinol. The expression of serum uric acid, NALP3 mRNA (P < 0. 040) and Caspase-1 mRNA (P < 0. 023) were significantly decreased in non-bustane group after treatment (P < 0. 05). The expression of), ASC mRNA was increased (P < 0. 043). There was significant difference between before and after treatment in non-bustane group. Conclusion NALP3 is associated with chronic gouty arthritis, and non-bustane can reduce uric acid and affect its function.
【作者单位】： 广州医科大学附属第三医院荔湾医院风湿科;广东省医学科学院 广东省人民医院风湿科;
【基金】：广东省科技厅科研基金项目(编号:2016ZC0151)
【分类号】：R589.7
【相似文献】
相关期刊论文 前10条
1 颜廷立;原发性痛风性关节炎78例分析[J];临床内科杂志;2000年01期
2 钱轶梅,胡学文;痛风性关节炎7例误诊分析[J];西安医科大学学报;2001年01期
3 曹洪国;23例痛风性关节炎临床及误诊分析[J];现代医药卫生;2001年10期
4 刘爱苓,杨宝旭;痛风性关节炎的疼痛治疗[J];中国冶金工业医学杂志;2005年03期
5 郑其凤;常金林;;中西医结合治疗痛风性关节炎35例[J];中国民族民间医药;2010年07期
6 乔，
本文编号：2434662
本文链接：https://www.wllwen.com/yixuelunwen/nfm/2434662.html
最近更新
教材专著
