新生期母子分离对大鼠2型糖尿病进程的影响

发布时间：2019-03-05 09:49

【摘要】：目的:明确新生期母婴分离是否改变成年期糖代谢及增加高脂饮食导致2型糖尿病的风险.方法:建立大鼠NMS模型,正常(NH)大鼠和NMS大鼠成年后高脂饮食干预2个月,检测大鼠体重、口服葡萄糖耐量和血压.结果:NMS大鼠成年后体重与NH大鼠体重无明显差别,但随着鼠龄的增长,NMS大鼠体重较NH大鼠体重增加;成年后大鼠经高脂饮食干预1个月或2个月,高脂饮食组NH和NMS大鼠分别较正常饮食组NH大鼠和NMS组体重明显增加;成年后NMS大鼠空腹血糖较NH大鼠低,但NMS大鼠口服葡萄糖后30 min的血糖值较NH大鼠高;NMS正常饮食组、NH高脂饮食组和NMS高脂饮食组口服葡萄糖后60、90、120 min的血糖值均比NH正常饮食组高;NMS高脂饮食组口服葡萄糖后90、120 min的血糖值均比NMS正常饮食组高;各组大鼠血压均无明显差异.结论:NMS可能导致大鼠糖耐量减低,体内糖代谢紊乱,可能增加发生2型糖尿病的敏感性.
[Abstract]:Objective: to determine whether neonatal mother-to-child separation changes glucose metabolism in adulthood and increases the risk of type 2 diabetes mellitus caused by high-fat diet. Methods: the NMS model of rats was established. Normal (NH) rats and NMS rats were treated with high fat diet for 2 months. The body weight, oral glucose tolerance and blood pressure of the rats were measured. Results: there was no significant difference in body weight between NMS rats and NH rats, but with the increase of age, the weight of NMS rats was higher than that of NH rats. Adult rats were treated with high fat diet for 1 month or 2 months. The weight of NH and NMS rats in high fat diet group was significantly higher than that in normal diet group NH rats and NMS group, respectively. The fasting blood glucose of adult NMS rats was lower than that of NH rats, but the glucose level of NMS rats was higher than that of NH rats 30 min after oral glucose administration. The blood glucose level of NMS normal diet group, NH high fat diet group and NMS high fat diet group was higher than that of NH normal diet group, and the blood glucose level of NMS high fat diet group was higher than that of NMS normal diet group after taking glucose 60, 90120 min, and 90120 min of NMS high fat diet group was higher than that of NMS normal diet group. There was no significant difference in blood pressure among the three groups. Conclusion: NMS may lead to impaired glucose tolerance and disorder of glucose metabolism in rats, which may increase the sensitivity of type 2 diabetes mellitus.
【作者单位】：广州医科大学药学院蛇毒与生物毒素研究所;香港浸会大学中医药学院;
【基金】：广州医科大学科学研究项目(2011C26)
【分类号】：R587.1

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