糖尿病足溃疡患者血清视黄醇结合蛋白4的水平变化及其临床意义

发布时间：2019-03-12 15:45

【摘要】：目的探讨糖尿病足溃疡(DFU)患者血清视黄醇结合蛋白4(RBP4)的水平及其临床意义。方法将2013年1月至2015年3月于临沂市河东区人民医院住院的158例T2DM患者分为单纯糖尿病组(DM组)80例和DFU组78例;再将DFU组按照Wagner分级标准和是否合并感染进行分级、分组;另取我院查体血糖正常的健康人80名作为对照组(NC组)。记录3组性别、年龄、糖尿病病程、BP、BMI、吸烟指数,测定FPG、2 hPG、HbA_1c、TG、TC、HDL-C、LDL-C、RBP4、同型半胱氨酸(Hcy)、高敏C反应蛋白(hsC-RP)、肝肾功能等指标,并对结果进行统计学分析。结果 (1)DFU组RBP4水平高于DM组和NC组[(105.61±17.48)vs(78.29±16.81)vs(53.27±15.92)mg/L](P0.01);(2)随Wagner分级的增加,RBP、Hcy、hsC-RP水平逐渐升高(P0.05);(3)合并感染DFU亚组(IDFU亚组)RBP4水平高于无感染DFU亚组(NIDFU亚组)[(112.58±21.86)vs(83.72±16.34)mg/L](P0.01)。(4)Spearman相关分析显示,DFU患者血清RBP4的水平与TG、LDL-C、HbA_1c、SBP、糖尿病病程、吸烟指数呈正相关。(5)Logistic回归分析显示,RBP4、Hcy是DFU的危险因素。结论 DFU患者RBP4水平升高,并与其严重程度及是否感染相关;RBP4的水平与TG、LDL-C、HbA_1c、糖尿病病程、吸烟指数呈正相关。
[Abstract]:Objective to investigate the serum retinol binding protein 4 (RBP4) levels in patients with diabetic foot ulcer (DFU) and its clinical significance. Methods from January 2013 to March 2015, T2DM patients in Hedong people's Hospital of Linyi City were divided into simple diabetic group (DM group, 80 cases) and DFU group (78 cases). The DFU group was divided into two groups according to the criteria of Wagner classification and infection or not, and 80 healthy persons with normal blood glucose in our hospital were taken as the control group (NC group). Sex, age, duration of diabetes mellitus, BP,BMI, smoking index, FPG,2 hPG,HbA_1c,TG,TC,HDL-C,LDL-C,RBP4, homocysteine (Hcy), and Gao Min C reactive protein (hsC-RP) were recorded. Liver and kidney function and other indicators, and the results of statistical analysis. Results (1) the level of RBP4 in DFU group was higher than that in DM group and NC group [(105.61 卤17.48) vs (78.29 卤16.81) vs (53.27 卤15.92) mg/L] (P0.01). (2) with the increase of Wagner classification, the level of RBP,Hcy,hsC-RP increased gradually (P0.05); (3) the level of RBP4 in the co-infected DFU subgroup (IDFU subgroup) was higher than that in the non-infected DFU subgroup (NIDFU subgroup) [(112.58 卤21.86) vs (83.72 卤16.34) mg/L] (P0.01). (4) Spearman correlation analysis. The level of serum RBP4 in patients with DFU was positively correlated with the course of diabetes and smoking index in TG,LDL-C,HbA_1c,SBP,. (5) Logistic regression analysis showed that RBP4,Hcy was a risk factor for DFU. Conclusion the level of RBP4 in patients with DFU is higher and correlated with its severity and infection, and the level of RBP4 is positively correlated with the course of diabetes mellitus and smoking index in TG,LDL-C,HbA_1c,.
【作者单位】：山东省临沂市河东区人民医院内分泌科;山东省立医院内分泌科;
【基金】：国家863计划子课题(2014AA022304)
【分类号】：R587.2

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