氟伐他汀联合阿司匹林对糖尿病性下肢动脉硬化闭塞症患者相关指标的影响

发布时间：2019-03-23 20:15

【摘要】：目的:探讨氟伐他汀联合阿司匹林对糖尿病性下肢动脉硬化闭塞症(LEAOD)患者相关指标的影响。方法:80例糖尿病性LEAOD患者随机分为对照组(40例)和观察组(40例)。在常规治疗基础上,对照组患者每晚口服瑞舒伐他汀钙片5 mg+阿司匹林肠溶片100 mg;观察组患者每晚口服氟伐他汀钠胶囊40 mg+阿司匹林肠溶片100 mg。两组疗程均为3个月。观察两组患者治疗前后纤维蛋白原、血浆D-二聚体、血液黏度、总胆固醇(TC)、三酰甘油(TG)、糖化血红蛋白(Hb A1c)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、颈动脉内膜厚度及TC、TG、Hb A1c、LDL-C、HDL-C达标情况、颈动脉内膜增厚、斑块形成、狭窄及闭塞患者例数,并记录不良反应发生情况。结果:治疗后,两组患者纤维蛋白原、血浆D-二聚体、血液黏度、TC、TG、Hb A1c、LDL-C、颈动脉内膜厚度均显著低于同组治疗前,且观察组显著低于对照组;两组患者HDL-C水平均显著高于同组治疗前,且观察组显著高于对照组,差异均有统计学意义(P0.05)。观察组患者TC、TG、LDL-C、HDL-C达标率均显著高于对照组,颈动脉内膜增厚、斑块形成患者占比均显著少于对照组,差异均有统计学意义(P0.05);两组患者Hb A1c达标率、颈动脉狭窄及闭塞患者占比、不良反应发生率比较,差异均无统计学意义(P0.05)。结论:氟伐他汀联合阿司匹林用于糖尿病性LEAOD,可显著改善患者血液黏度、血脂和血管内皮功能,减少血栓疾病的发生风险,且未增加不良反应的发生。
[Abstract]:Objective: to investigate the effect of fluvastatin combined with aspirin on (LEAOD) in patients with diabetic arteriosclerosis obliterans. Methods: 80 patients with diabetic LEAOD were randomly divided into control group (n = 40) and observation group (n = 40). On the basis of routine treatment, the patients in the control group were given Risuvastatin calcium tablets 5 mg aspirin enteric-coated tablets every night 100 mg; in the observation group patients in the observation group were given fluvastatin sodium capsules 40 mg aspirin enteric-coated tablets 100 mg. every night in the observation group. The course of treatment in both groups was 3 months. Before and after treatment, fibrinogen, plasma D-dimer, blood viscosity, total cholesterol (TC), triacylglycerol (TG), glycosylated hemoglobin (Hb A1c) and low density lipoprotein cholesterol (LDL-C) were observed. High density lipoprotein cholesterol (HDL-C), carotid intima thickness and TC,TG,Hb A1c, LDL / C, HDL / C, carotid intima thickening, plaque formation, stenosis and occlusion were recorded. The incidence of adverse reactions was also recorded in patients with high density lipoprotein cholesterol (HDL-C), carotid artery intima-media thickness and TC,TG,Hb-A1c, LDL-C and HDL-C. Results: after treatment, fibrinogen, plasma D-dimer, blood viscosity, TC,TG,Hb A1c, LDL-C and carotid intima thickness in the two groups were significantly lower than those in the control group before treatment, and in the observation group were significantly lower than those in the control group. The levels of HDL-C in the two groups were significantly higher than those before treatment in the same group, and the level in the observation group was significantly higher than that in the control group, the difference was statistically significant (P0.05). The rate of TC,TG,LDL-C,HDL-C reaching the standard in the observation group was significantly higher than that in the control group, the carotid intima thickening and the percentage of plaque formation in the observation group were significantly lower than those in the control group, the difference was statistically significant (P0.05). There was no significant difference in the rate of Hb A1c, the proportion of patients with carotid stenosis and occlusion, and the incidence of adverse reactions between the two groups (P0.05). Conclusion: fluvastatin combined with aspirin can significantly improve the blood viscosity, blood lipid and vascular endothelial function, reduce the risk of thrombosis, and does not increase the incidence of adverse reactions in patients with diabetic LEAOD,.
【作者单位】：河北工程大学医学院康复治疗系;河北工程大学附属医院呼吸科;邯郸市第一医院内分泌科;
【分类号】：R543.5

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