降糖药物基因组学研究进展

发布时间：2019-04-21 12:02

【摘要】：精准医学是一种预防和治疗疾病的新方法。美国负责设计"精准医学"项目包括糖尿病。糖尿病的发生发展以及分型受遗传和环境因素的双重影响,基于基因多态性研究调节血糖药物基因组学,有助于根据特定的基因亚型选择合适的降糖药物并且调整药物剂量,对于糖尿病患者个体化用药、提高疗效、减少副反应等都具有重要意义。本文基于基因组学和精准医学的理念,对各类降糖药物基因组学研究进展进行综述,以期为精准医学在糖尿病领域的实践提供理论依据。
[Abstract]:Precise medicine is a new method to prevent and treat diseases. The United States is responsible for designing "precision medicine" programs including diabetes. The occurrence and development of diabetes mellitus is influenced by both genetic and environmental factors. The study of regulating blood glucose pharmacogenomics based on gene polymorphism helps to select appropriate hypoglycemic drugs and adjust drug doses according to specific gene subtypes. It is of great significance for individual use of drugs, improvement of curative effect and reduction of side effects in patients with diabetes mellitus. Based on the concepts of genomics and precision medicine, this paper reviews the advances in genomics of various hypoglycemic drugs in order to provide a theoretical basis for the practice of precision medicine in the field of diabetes.
【作者单位】：四川大学华西医院药剂科;
【分类号】：R587.1

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