非布司他对高尿酸血症大鼠血清白介素6和转化生长因子β1水平的影响

发布时间：2019-04-22 18:37

【摘要】：目的观察高尿酸血症(HUA)大鼠血尿酸(SUA)与IL-6、转化生长因子β1(TGF-β1)的关系,以及非布司他对HUA大鼠血清IL-6和TGF-β1的影响。方法 SD大鼠随机分为对照组(Con)、模型组和非布司他干预组,每组12只,分别于第0、4、8周末检测大鼠24 h尿蛋白(24 hU;Alb),SUA、血肌酐(Scr)、BUN、IL-6和TGF-β1。采用HE及Masson染色法观察肾脏病理学改变。结果模型组及非布司他干预组SUA、Scr、BUN、IL-6和TGF-β1高于Con组(P0.05),模型组IL-6和TGF-β1较非布司他干预组升高(P0.05或P0.01)。相关分析显示,血清IL-6与SUA、TGF-β1、Scr及24 hUAlb呈正相关(r=0.908、0.827、0.848、0.855,P0.01);非布司他治疗能降低SUA、IL-6及TGF-β1水平(P0.05)。肾脏病理学改变以模型组损伤最明显,非布司他治疗后肾脏损伤减轻。结论非布司他对HUA有明显的治疗作用,在降尿酸的同时还可降低IL-6及TGF-β1,减轻肾脏炎症反应,对肾脏功能和形态的损伤有很好的保护作用。
[Abstract]:Aim to observe the relationship between serum uric acid (SUA) and IL-6, transforming growth factor 尾 1 (TGF- 尾 1) in (HUA) rats with hyperuricemia, and the effect of non-bustane on serum IL-6 and TGF- 尾 1 in HUA rats. Methods SD rats were randomly divided into control group (Con), model group) and non-bustane intervention group (n = 12). 24-hour urinary protein (24 hU;Alb), SUA, creatinine (Scr), BUN,IL-6 and TGF- 尾 1.) were measured at the end of 0,4,8 weeks respectively. The pathological changes of kidney were observed by HE and Masson staining. Results the levels of SUA,Scr,BUN,IL-6 and TGF- 尾 1 in model group and non-bustane intervention group were higher than those in Con group (P 0.05). The levels of IL-6 and TGF- 尾 1 in model group were higher than those in non-bustane intervention group (P0.05 or P0.01). Correlation analysis showed that serum IL-6 was positively correlated with SUA,TGF- 尾 1, Scr and 24 hUAlb (r = 0.908,0.827,0.848,0.848,0.855, P0.01), and non-bustane treatment decreased the levels of SUA,IL-6 and TGF- 尾 1 (P0.05). The pathological changes of kidney were most obvious in the model group, and the renal injury was alleviated after non-bustane treatment. Conclusion non-bustane has obvious therapeutic effect on HUA. It can decrease the level of IL-6 and TGF- 尾 1, reduce the inflammatory reaction of kidney and protect the function and morphology of kidney from injury at the same time of decreasing uric acid. [WT5 "HZ] conclusion [WT5" HZ] [WT5 "BZ]
【作者单位】：南方医科大学;中国人民解放军第305医院内分泌科;
【基金】：总参军事医学和老年病科研基金(ZCWS14B12)
【分类号】：R589.7

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