甘肃省成人甲状腺功能减退症患病率流行病学调查及相关因素分析

发布时间：2019-05-06 12:44

【摘要】：目的甲状腺功能减退症(甲减)是临床较常见的内分泌疾病,随着人们健康意识的提高和对甲状腺疾病的不断深入了解,甲减日益受到人们的重视。本次研究主要目的是为了了解甘肃省成人甲减(包括临床甲状腺功能减退症、亚临床甲状腺功能减退症)患病率及流行病学特点,同时分析甲减相关生活方式及代谢影响因素,为开展甘肃省甲减防治工作提供参考依据。方法采用多阶段分层随机抽样的方法在甘肃省的七个市(州)抽取11268名成人进行调查,每位被调查者均需填写调查问卷,并进行体格检查、静脉血采集。结果1.甘肃省成人甲减患病率为9.82%,其中,亚临床功能减退症(亚甲减)患病率远远高于临床甲状腺功能减退症(临床甲减)(8.40%vs1.42%)。女性甲减患病率明显高于男性(11.72%vs7.27%)。2.多因素logic回归分析结果提示除了女性(OR:1.448,95%CI:(1.050,1.996),P=0.024)、年龄(OR:1.013,95%CI:(1.002,1.024),P=0.016)、WHR(OR:6.500,95%CI:(2.215,19.075),P=0.001)、BMI(OR:1.997,95%CI:(1.072,3.423),P=0.036),甲状腺家族史(OR:2.349,95%CI:(1.791,3.082),P0.001)是甲减的危险因素,吸烟史(OR:0.289,95%CI:(0.089,,0.940),P=0.039)、饮食口味偏咸(OR:0.298,95%CI:(0.165,0.541),P0.001)、经常食用海产品(OR:0.457,95%CI:(0.294,0.711),P=0.002)可能对甲减的发生发展起到保护性作用。3.多因素Logistic回归分析结果提示血清甲状腺过氧化物酶抗体阳性(OR:2.419,95%CI:1.160,5.043,P=0.018)、甲状腺球蛋白抗体阳性(OR:1.976,95%CI:1.037,3.768,P=0.039)或血清高甘油三酯(OR:1.241,95%CI:1.044,1.474,P=0.014)对甲减的发生有促进作用。结论甘肃省成人甲状腺功能减退症患病率较高,约占全部人口的十分之一,年龄、女性、甲状腺自身抗体阳性、相关生活方式(吸烟史、食盐口味偏好、海产品的进食情况)及高血清甘油三酯均对甲减的发生发展有一定影响,养成健康的工作和生活方式,关注血脂的控制有利于预防甲减的发生。
[Abstract]:Objective hypothyroidism (hypothyroidism) is a common endocrine disease in clinic. With the improvement of people's health consciousness and further understanding of thyroid disease, hypothyroidism has been paid more and more attention. The main purpose of this study is to understand the prevalence and epidemiological characteristics of adult hypothyroidism (including clinical hypothyroidism and subclinical hypothyroidism) in Gansu Province, and to analyze the related lifestyle and metabolic factors of hypothyroidism. In order to carry out the work of prevention and control of hypothyroidism in Gansu Province, provide reference basis. Methods 11268 adults were selected from seven cities (prefectures) of Gansu province by multi-stage stratified random sampling. Each interviewee was asked to fill in the questionnaire, carry out physical examination and collect venous blood. Outcome 1. The prevalence of hypothyroidism in adults in Gansu Province was 9.82%, and the prevalence rate of subclinical hypothyroidism was much higher than that of clinical hypothyroidism (8.40% vs 1.42%). The prevalence of hypothyroidism in females was significantly higher than that in males (11.72% vs 7.27%). Multivariate logic regression analysis showed that except for women (OR:1.448,95%CI: (1.050, 1.996), P < 0.024), age (OR:1.013,95%CI: (1.002, 1.024), P = 0.016), WHR (OR:6.500,95%CI: (2.215, 19.075), P < 0.001), BMI (OR:1.997,95%CI: (1.072, 3.423), P = 0.036), family history of thyroid gland (OR:2.349,95%CI: (1.791, 3.082), P0.001) is a risk factor for hypothyroidism, history of smoking (OR:0.289,95%CI: (0.089, 0.940), P0. 039), and a salty diet (OR:0.298,95%CI: (0.165, 0.541), P0.001), Frequent consumption of seafood (OR:0.457,95%CI: (0.294, 0.711), P < 0.002) may play a protective role in the occurrence and development of hypothyroidism. 3. Multivariate Logistic regression analysis showed that serum thyroid peroxidase antibody (OR:2.419,95%CI:1.160,5.043,P=0.018) and thyroglobulin antibody (OR:1.976,95%CI:1.037,3.768,) were positive. P0. 039) or serum hypertriglycerides (OR:1.241,95%CI:1.044,1.474,P=0.014) could promote the occurrence of hypothyroidism. Conclusion the prevalence rate of adult hypothyroidism in Gansu province is higher, accounting for about 1/10 of the total population, age, female, thyroid autoantibody positive, related lifestyle (smoking history, salt taste preference, etc.) The occurrence and development of hypothyroidism were influenced by diet of seafood and high serum triglyceride. To develop a healthy work and life style and pay attention to the control of blood lipid were helpful to prevent the occurrence of hypothyroidism.
【学位授予单位】：宁夏医科大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R581.2

【相似文献】