运动锻炼及雌激素受体-β基因多态性与老年女性骨质疏松的相关性
发布时间：2019-05-07 11:52
【摘要】：目的研究运动锻炼及雌激素受体(ER)-β基因多态性与女性老年性骨质疏松(ADOP)的相关性。方法 420例长期运动锻炼老年女性和415例非长期运动锻炼老年女性,定量超声骨质密度仪检测两组右侧足跟骨宽带超声衰减值,PCR-RFLP检测两组ER-β基因多态性。结果长期运动锻炼组ADOP的患病率明显低于非长期运动锻炼组(P0.01)。ER-β基因RsaⅠ等位基因分布频率在两组中存在显著差异(P0.01),r等位基因患ADOP的风险是R等位基因的1.565倍(OR=1.565,95%CI:1.270~1.928)。长期运动锻炼组携带AluⅠ酶切位点的a等位基因分布频率明显少于非长期运动锻炼组(P0.01)。结论长期运动锻炼对ADOP有防治作用。ER-βRsaⅠ酶切位点的r等位基因可能是ADOP的遗传易感基因。AluⅠ酶切位点的a等位基因是对运动锻炼的敏感基因。
[Abstract]:Objective to study the relationship between exercise and estrogen receptor (ER)-尾 gene polymorphism and senile osteoporosis (ADOP) in women. Methods Wideband ultrasonic attenuation of right calcaneus was measured by quantitative ultrasound bone densitometer and ER- 尾 gene polymorphism was detected by PCR-RFLP in 420 elderly women with long-term exercise and 415 elderly women with non-long-term exercise. Results the prevalence of ADOP in the long-term exercise group was significantly lower than that in the non-long-term exercise group (P0.01). The frequency of Rsa 鈪，
本文编号：2471054
[Abstract]:Objective to study the relationship between exercise and estrogen receptor (ER)-尾 gene polymorphism and senile osteoporosis (ADOP) in women. Methods Wideband ultrasonic attenuation of right calcaneus was measured by quantitative ultrasound bone densitometer and ER- 尾 gene polymorphism was detected by PCR-RFLP in 420 elderly women with long-term exercise and 415 elderly women with non-long-term exercise. Results the prevalence of ADOP in the long-term exercise group was significantly lower than that in the non-long-term exercise group (P0.01). The frequency of Rsa 鈪，
本文编号：2471054
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