精准医疗下的肥胖症基础与临床研究

发布时间：2019-05-11 05:11

【摘要】：肥胖在我国和世界范围均已成为严重的健康问题。在人类进入精准医学时代,随着基因组学等分子生物学的技术进步,肥胖的基础与临床研究取得了很大的进展。但由于肥胖是大量异质性很大的疾病群构成,随着精准医学研究的深入,对曾经认同的肥胖的诊断和分类提出了诸多挑战,目前仍缺少可用于临床实践和商业化的疾病预测模型。在肥胖研究中,经典细胞因子和脂肪因子外的胃肠激素及相关分子、摄食相关信号通路蛋白等蛋白分子标志物和肠道基因组学等分子生物学研究是精准医疗研究的基础,加强整合个体化及群体性的分子生物学和遗传学研究,最终为肥胖症在精准医疗下向临床应用转化奠定基础。
[Abstract]:Obesity has become a serious health problem in China and the world. In the era of precision medicine, with the technological progress of genomics and other molecular biology, great progress has been made in the basic and clinical research of obesity. However, because obesity is a large number of heterogeneous disease groups, with the deepening of precision medical research, there are many challenges to the diagnosis and classification of obesity. At present, there is still a lack of disease prediction models that can be used in clinical practice and commercialization. In the study of obesity, gastrointestinal hormones and related molecules outside classical cytokines and fat factors, protein molecular markers such as feeding related signaling pathway proteins and molecular biology such as intestinal genomics are the basis of accurate medical research. To strengthen the integration of individualized and group molecular biology and genetics research, and finally lay the foundation for the transformation of obesity into clinical application under accurate medical treatment.
【作者单位】：四川大学华西医院内分泌代谢科;四川大学华西医院全科医学科;
【基金】：国家自然科学基金(No.81400811和No.21534008)资助
【分类号】：R589.2

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