抵抗素水平和老年2型糖尿病患者心血管病变的关系

发布时间：2019-05-19 16:45

【摘要】：目的探讨抵抗素与老年2型糖尿病(T2DM)及其心血管病的关系。方法选择60例老年T2DM患者并测定抵抗素水平,患者年龄62~66岁,糖尿病平均病程为(10.2±2.4)年,在24个月的随访中,记录致死性心血管病和非致死性心血管病事件,多因素Cox回归分析心血管病的发病风险。结果根据患者血清抵抗素中位值293.25 pg/ml进行分组,结果显示性别分布、糖尿病病程、胰岛素治疗、体重指数(BMI)、生化结果和既往心血管事件均无显著差异。在24个月的随访中,6例(10.00%)老年T2DM患者死于心血管疾病,14例(23.33%)发生了一次非致死性心血管病。血清抵抗素水平≥293.25 pg/ml组在致死性和非致死性心血管病变的联合终点发生率明显增高(P=0.001)。多因素Cox回归分析显示,抵抗素水平≥中位值者在联合终点事件的发生风险明显增高(HR:5.73,95%CI:1.91~17.23)。结论根据抵抗素水平可评估老年T2DM的预后,对老年T2DM患者心血管病的危险分层提供依据。
[Abstract]:Objective to investigate the relationship between resistin and type 2 diabetes mellitus (T2DM) and cardiovascular disease in the elderly. Methods 60 elderly patients with T2DM were selected and resistin levels were measured. The average course of diabetes mellitus was (10.2 卤2.4) years. The events of fatal cardiovascular disease and non-fatal cardiovascular disease were recorded during 24 months follow-up. Multivariate Cox regression analysis was used to analyze the risk of cardiovascular disease. Results the patients were divided into two groups according to the median serum resistin value of 293.25 pg/ml. The results showed that there were no significant differences in sex distribution, course of diabetes, insulin treatment, body mass index (BMI),) biochemical results and previous cardiovascular events. During the 24-month follow-up, 6 (10.00%) elderly patients with T2DM died of cardiovascular disease and 14 (23.33%) developed non-fatal cardiovascular disease. The incidence of combined end point of fatal and non-fatal cardiovascular disease was significantly increased in patients with serum resistin level 鈮，

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