阿卡波糖联合二甲双胍对2型糖尿病患者相关指标的影响

发布时间：2019-06-01 17:51

【摘要】：目的:探讨阿卡波糖联合二甲双胍对2型糖尿病患者相关指标的影响。方法:100例2型糖尿病患者随机分为对照组(50例)和观察组(50例)。对照组患者给予阿卡波糖片50 mg,口服,每日3次;观察组患者在对照组治疗的基础上给予盐酸二甲双胍片0.5 g,口服,每日3次。两组疗程均为12周。观察两组患者治疗前后空腹血糖(FPG)、空腹血浆胰岛素(FINS)、糖化血红蛋白(Hb A1c)、餐后2 h血糖(2 h PG)、餐后2 h胰岛素(2 h FINS)、胰岛素抵抗指数(HOMA-IR)、CD4~+T细胞中各Th细胞亚群比例、白细胞介素22(IL-22)、IL-17A、干扰素-γ(IFN-γ)水平及IL-22 m RNA、IL-17A m RNA、IFN-γm RNA表达水平,并记录不良反应发生情况。结果:治疗后,两组患者FPG、FINS、Hb A1c、2 h PG、2 h FINS、HOMA-IR、CD4~+T细胞中各Th细胞亚群比例、IL-22、IL-17A、IFN-γ水平及IL-22 m RNA、IL-17A m RNA、IFN-γm RNA表达水平均显著低于同组治疗前,差异均有统计学意义(P0.05);两组间除CD4~+T细胞中Th1细胞亚群比例比较差异无统计学意义(P0.05)外,其他指标均为观察组显著低于对照组,差异均有统计学意义(P0.05)。两组患者不良反应发生率比较,差异无统计学意义(P0.05)。结论:阿卡波糖联合二甲双胍可有效控制2型糖尿病患者的血糖,改善胰岛抵抗状态,平衡Th细胞亚群,降低炎性细胞因子水平,且未增加不良反应的发生。
[Abstract]:Objective: to investigate the effect of acarbose combined with metformin on the related indexes of type 2 diabetes mellitus (T2DM). Methods: 100 patients with type 2 diabetes mellitus were randomly divided into control group (n = 50) and observation group (n = 50). The patients in the control group were given acarbose tablets 50 mg, 3 times a day, and the patients in the observation group were given metformin hydrochloride tablets 0.5 g, 3 times a day, on the basis of treatment in the control group. The course of treatment in both groups was 12 weeks. Fasting plasma glucose (FPG), fasting plasma insulin (FINS), glycosylated hemoglobin (Hb A1c) and postmeal blood glucose (2 h PG), 2 h insulin (2 h FINS),) were observed in both groups before and after treatment. Insulin resistance index (HOMA-IR), proportion of Th cell subsets in CD4~ T cells, IL-22 (IL-22), IL-17A, interferon-gamma (IFN- 纬) levels and IL-22 m RNA,IL-17A m RNA,IFN- 纬 m RNA expression levels. The occurrence of adverse reactions was recorded. Results: after treatment, the proportion of Th cell subsets, the level of IL-22,IL-17A,IFN- 纬 and IL-22 m RNA,IL-17A m RNA, in FPG,FINS,Hb A1c, PG,2 h FINS,HOMA-IR,CD4~ T cells in the two groups were 2 h. The expression level of IFN- 纬 m RNA in the same group was significantly lower than that in the same group before treatment (P 0.05). There was no significant difference in the proportion of Th1 cell subsets in CD4~ T cells between the two groups (P 0.05), but the other indexes in the observation group were significantly lower than those in the control group (P 0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P 0.05). Conclusion: acarbose combined with metformin can effectively control blood glucose, improve islet resistance, balance Th cell subsets, decrease the level of inflammatory cytokines, and do not increase the occurrence of adverse reactions.
【作者单位】：广州市东升医院西医内科;广州市东升医院检验科;广州中医药大学第一附属医院脑病科;广州市东升医院治疗科;
【基金】：广东省中医药局科研课题(No.20142062)
【分类号】：R587.1

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