载脂蛋白E对绝经后妇女骨质疏松影响的研究进展

发布时间：2019-06-06 08:56

【摘要】：载脂蛋白E(Apolipoprotein E,Apo E)在脂代谢中起核心作用,载脂蛋白E不仅作为重要角色参与脂代谢,也同时会影响骨代谢。现阶段多种研究表明,骨质疏松与脂代谢异常是受各种原因影响的代谢性疾病,二者关系紧密,绝经后妇女由于雌激素水平变化,常导致骨代谢与脂代谢紊乱,同时雌激素水平也被证实对Apo E有较大影响。国内外学者多将绝经后妇女骨质疏松与脂代谢异常的着重点放于Apo E,集中研究Apo E对骨代谢与脂代谢的调节作用。骨代谢与脂代谢的异常在我国中老年妇女人群中出现率极高,且往往伴随发生。骨质疏松对中老年妇女的日常生活,甚至生命安全皆有重要影响。本文通过整理载脂蛋白E对骨代谢以及绝经后妇女骨质疏松影响的现阶段研究,进一步对其相关性制作综述。
[Abstract]:Apolipoproteins E (Apolipoprotein E (Apo E) play a central role in lipid metabolism. Apolipoproteins E not only play an important role in lipid metabolism, but also affect bone metabolism. At present, a variety of studies have shown that osteoporosis and abnormal lipid metabolism are metabolic diseases affected by various reasons, which are closely related to each other. Postmenopausal women often lead to disorder of bone metabolism and lipid metabolism due to the change of estrogen level. At the same time, estrogen level has also been confirmed to have a great impact on Apo E. Most scholars at home and abroad focus on the regulation of bone metabolism and lipid metabolism in postmenopausal women with osteoporosis and lipid metabolism, and focus on the regulatory effect of Apo E on bone metabolism and lipid metabolism. The abnormality of bone metabolism and lipid metabolism is very high in middle-aged and elderly women in China, and often accompanied by the occurrence of abnormal bone metabolism and lipid metabolism in middle-aged and elderly women in China. Osteoporosis has an important impact on the daily life and even life safety of middle-aged and elderly women. In this paper, the effects of apolipoproteins E on bone metabolism and osteoporosis in postmenopausal women were reviewed.
【作者单位】：南京中医药大学第二临床医学院;南京中医药大学附属医院;
【基金】：江苏省研究生科研创新计划项目(KYZZ15-0272) 南京市科学技术委员会医疗卫生科技项目(201611008) 江苏省卫生计生委员干部保健局(BJ16019)
【分类号】：R580

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