来曲唑与尿促性素在多囊卵巢综合征不孕患者促排卵中的应用

发布时间：2019-06-14 22:47

【摘要】：目的分析来曲唑(letrozole,LE)与尿促性素(human menopausal gonadotmpin,HMG)在多囊卵巢综合征(polycystic ovary syndrome,PCOS)不孕患者促排卵中的疗效。方法选取112例多囊卵巢综合征不孕患者,分为A、B两组,A组(来曲唑组)、B组(来曲唑与尿促性素组),B组HMG用法为隔日肌内注射1次。观察两组成熟卵泡数、成熟卵泡率、排卵率、临床妊娠率、异位妊娠数及早期流产率等。结果两组基础性激素水平、BMI、成熟卵泡数、排卵率差异均无统计学意义(P0.05);妊娠率两组分别为26.7%和41.6%,差异有统计学意义(P=0.046),说明B组临床妊娠率优于A组;B组中HMG的周期平均用量为5.12支(532/104)。A组3例早期流产,3例多胎妊娠;B组2例自然流产,1例异位妊娠,5例多胎妊娠,差异无统计学意义(P0.05)。结论对于多囊卵巢综合征不孕患者进行促排卵治疗,LE与HMG联合应用且HMG隔日肌内注射1次的方案优于单用LE。
[Abstract]:Objective to analyze the efficacy of letrozole (letrozole,LE) and urogonadotropin (human menopausal gonadotmpin,HMG) in ovulatory induction in infertile patients with polycystic ovarian syndrome (polycystic ovary syndrome,PCOS). Methods 112infertile patients with polycystic ovarian syndrome were divided into two groups: group A, group B, group A (group), B, letrozole group, group), B, intramuscular injection of HMG once every other day). The number of mature follicles, mature follicles rate, ovulatory rate, clinical pregnancy rate, ectopic pregnancy rate and early abortion rate were observed. Results there was no significant difference in the level of basic hormones, the number of mature follicles and ovulatory rate between the two groups (P < 0.05), and the pregnancy rate was 26.7% and 41.6% in the two groups (P 鈮，

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