泻火消瘿方联合甲巯咪唑片治疗毒性弥漫性甲状腺肿心肝火旺证30例临床观察

发布时间：2019-06-24 10:43

【摘要】：目的观察泻火消瘿方治疗毒性弥漫性甲状腺肿(又称Graves病)心肝火旺证的临床疗效。方法将80例Graves病心肝火旺证患者随机分为治疗组和对照组各40例,对照组给予甲巯咪唑片治疗,治疗组在对照组基础上加用泻火消瘿方,每日1剂。两组均以4周为1个疗程,连续治疗3个疗程。比较两组患者治疗前后心率、体重、中医证候积分;检测治疗前及治疗1、2、3个疗程甲状腺功能[包括促甲状腺激素(TSH)、游离三碘甲状腺原氨酸(FT3)、游离甲状腺素(FT4)],计算各指标恢复率及恢复至正常水平所需平均时间;检测治疗前后促甲状腺激素受体抗体(TRAb)水平;记录各疗程甲巯咪唑片用量。结果最终有61例患者完成研究,治疗组30例,对照组31例。治疗组在降低心率及中医证候积分方面优于对照组(P0.05或P0.01);与对照组比较,治疗组在1、2疗程时FT3、FT4水平更低,FT3、FT4恢复正常所需时间更少且治疗1个疗程时恢复率更高(P0.05或P0.01);治疗组在1、2、3疗程时甲巯咪唑片用量均低于同时间对照组(P0.05或P0.01)。两组患者治疗后均较治疗前体重增加,TSH水平升高,TRAb水平降低(P0.01),治疗后两组各指标比较差异无统计学意义(P0.05)。结论泻火消瘿方治疗Graves病心肝火旺证可迅速改善临床症状及甲状腺功能,并能减少西药用量。
[Abstract]:Objective to observe the clinical effect of Xiehuxiaoying recipe in the treatment of toxic disseminated goiter (also known as Graves's disease). Methods 80 patients with Graves syndrome were randomly divided into treatment group (n = 40) and control group (n = 40). The control group was treated with methimidazolium tablets, and the treatment group was treated with Xiehuoxiaoying recipe 1 dose a day on the basis of the control group. Both groups were treated with 4 weeks as a course of treatment and 3 consecutive courses of treatment. Heart rate, body weight and TCM syndrome score were compared between the two groups before and after treatment, thyroid function (including thyrotropin (TSH), free triiodothyronine (FT3), free thyroxine (FT4) was measured before and after treatment, the recovery rate of each index and the average time needed to return to normal level were calculated, and the level of thyrotropin receptor antibody (TRAb) was measured before and after treatment. The dosage of methimidazolium tablets in each course of treatment was recorded. Results 61 patients completed the study, 30 in the treatment group and 31 in the control group. The treatment group was superior to the control group in reducing heart rate and TCM syndrome score (P 0.05 or P 0.01). Compared with the control group, the level of FT3,FT4 in the treatment group was lower than that in the control group, the time needed for FT3,FT4 to return to normal was less and the recovery rate was higher in one course of treatment (P 0.05 or 0.01). The dosage of methimidazolium tablets in the treatment group was lower than that in the control group at 1, 2 and 3 courses of treatment (P 0.05 or P 0.01). After treatment, the body weight of the two groups increased, the level of TSH increased, and the level of TRAb decreased (P 0.01). There was no significant difference between the two groups after treatment (P 0.05). Conclusion Xiehuxiaoying recipe can rapidly improve clinical symptoms and thyroid function and reduce the dosage of western medicine in the treatment of Graves disease.
【作者单位】：南京中医药大学附属中西医结合医院;
【分类号】：R581.3

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