雷公藤多苷片联合复方α-酮酸片治疗糖尿病肾病的临床观察

发布时间：2019-06-24 21:14

【摘要】：目的:观察雷公藤多苷片联合复方α-酮酸片治疗糖尿病肾病(DN)的疗效和安全性。方法:186例糖尿病肾病患者随机分为对照组(93例)和研究组(93例)。在常规治疗的基础上,对照组患者给予雷公藤多苷片20 mg,口服,每日3次;研究组患者在对照组治疗的基础上给予复方α-酮酸片3.78 g,口服,每日3次。两组均连续治疗3个月。观察两组患者的临床疗效,治疗前肾功能[肌酐(Scr)、尿素氮(BUN)、胱抑素C(Cys C)、肾小球滤过率(GFR)、24 h尿蛋白]、肾间质纤维化指标[血清同型半胱氨酸(Hcy)、血管内皮生长因子(VEGF)、肝细胞生长因子(HGF)、转化生长因子β_1(TGF-β_1)]、氧化应激指标[总抗氧化能力(T-AOC)、超氧化物歧化酶(SOD)、晚期蛋白氧化产物(AOPP)、丙二醛(MDA)]水平及不良反应发生情况。结果 :两组患者治疗过程中未出现患者脱落,均完成治疗。研究组患者总有效率(91.39%)显著高于对照组(80.65%),差异有统计学意义(P0.05)。治疗后,两组患者Scr、BUN、Cys C、24 h尿蛋白、Hcy、VEGF、TGF-β_1、AOPP、MDA水平均显著低于同组治疗前,且研究组显著低于对照组;两组患者GFR、HGF、T-AOC、SOD水平均显著高于同组治疗前,且研究组显著高于对照组,差异均有统计学意义(P0.05)。两组患者不良反应发生率比较,差异无统计学意义(P0.05)。结论 :雷公藤多苷片联合复方α-酮酸片治疗DN的疗效显著,且未增加不良反应的发生。
[Abstract]:Objective: to observe the efficacy and safety of Tripterygium wilfordii polyglycoside tablets combined with compound 伪-ketoacid tablets in the treatment of diabetic nephropathy (DN). Methods: 186 patients with diabetic nephropathy were randomly divided into control group (93 cases) and study group (93 cases). On the basis of routine treatment, the patients in the control group were given Tripterygium wilfordii polyglycosides tablets for 20 mg, three times a day, and the patients in the study group were given compound 伪-ketoacid tablets 3.78 g, three times a day, on the basis of treatment in the control group. Both groups were treated continuously for 3 months. To observe the clinical efficacy of the two groups before treatment, renal function [creatine (Scr), urea nitrogen (BUN), cystine C (Cys C), glomerular filtration rate (GFR), 24 h urine protein], renal interstitial fibrosis index [serum homocysteine (Hcy), vascular endothelial growth factor (VEGF), (HGF), transforming growth factor 尾 _ 1 (TGF- 尾 _ 1)], and renal interstitial fibrosis index [serum homocysteine (Hcy), vascular endothelial growth factor (VEGF), (HGF), transforming growth factor 尾 _ 1 (TGF- 尾 _ 1)], Oxidative stress index [total antioxidant capacity (T-AOC), (SOD), late protein oxidation product (AOPP), malondialdehyde (MDA)] and adverse reactions. Results: no patients fell off during the treatment in both groups, and both groups completed the treatment. The total effective rate of the patients in the study group (91.39%) was significantly higher than that in the control group (80.65%), the difference was statistically significant (P 0.05). After treatment, the levels of Scr,BUN,Cys C, 24 h urinary protein, Hcy,VEGF,TGF- 尾 1 and AOPP in the two groups were significantly lower than those in the same group before treatment, and those in the study group were significantly lower than those in the control group, and the levels of GFR,HGF,T-AOC,SOD in the two groups were significantly higher than those in the control group before treatment, and the difference was statistically significant (P 0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P 0.05). Conclusion: Tripterygium wilfordii polyglycoside tablets combined with compound 伪-ketoacid tablets are effective in the treatment of DN and do not increase the occurrence of adverse reactions.
【作者单位】：武汉市普仁医院;
【分类号】：R587.2;R692.9

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