miR对骨质疏松骨代谢信号通路影响的研究进展

发布时间：2019-07-25 14:09

【摘要】：miR在骨骼发育、代谢过程中具有重要的生物学功能,能够调控骨细胞生长、分化和功能表达。正常机体中,骨代谢相关信号通路对维持骨骼正常生物学功能意义重大,miR通过与骨代谢相关的多种信号通路调节成骨细胞/破骨细胞代谢,达到有利于机体的平衡状态,如果miR表达失调这种稳态就会失衡,相关信号通路被激活,导致相应的骨代谢疾病,如骨质疏松症。信号通路作为调控骨代谢的重要途径,不同信号通路机制之间存在一定的联系,但是大多数信号通路的确切机制还不明了,各通路之间的相互联系研究较少,随着表观遗传学的发展,miR通过相关信号通路精密调控骨代谢的机制被逐步阐明。miR与多种骨质疏松多种信号通路存在密切的关系,成为潜在的检测标志物和治疗靶向点。研究miR参与调控骨质疏松骨代谢相关信号通路的机制,在骨质疏松的预防、诊治及预后意义重大。本文将从三个方面对近年来miR对骨质疏松症骨代谢相关信号通路的研究作以概述。
[Abstract]:MiR plays an important biological role in bone development and metabolism, and can regulate the growth, differentiation and functional expression of osteoblasts. In normal body, bone metabolism related signal pathway is of great significance to maintain the normal biological function of bone. MiR adjusts osteoblast / osteoclast metabolism through a variety of signal pathways related to bone metabolism, which is beneficial to the balance of the body. If the homeostasis of miR expression is imbalance, the related signal pathway will be activated, resulting in corresponding bone metabolic diseases, such as osteoporosis. As an important way to regulate bone metabolism, there is a certain relationship between different signal pathway mechanisms, but the exact mechanism of most signal pathways is not clear, and the study of the relationship between the pathways is less. With the development of epigenetics, the mechanism of miR precise regulation of bone metabolism through related signal pathways has been gradually clarified. MiR has a close relationship with a variety of osteoporosis signaling pathways. Become a potential detection marker and treatment target. To study the mechanism of miR involved in the regulation of bone metabolism-related signaling pathway in osteoporosis is of great significance in the prevention, diagnosis, treatment and prognosis of osteoporosis. In this paper, the study of bone metabolism related signal pathway in osteoporosis by miR in recent years is summarized from three aspects.
【作者单位】：甘肃中医药大学甘肃中医药大学附属医院
【基金】：国家自然科学基金(81360554) 甘肃省重点中医药现代制药工程研究院自立项目(YWW-2015049) 甘肃省中医药防治慢性疾病重点实验室(BH2010-428)
【分类号】：R580

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