糖尿病足感染病原菌分布以及血清炎症因子水平改变的研究

发布时间：2019-08-19 09:26

【摘要】：目的检测2型糖尿病患者并发糖尿病足感染的病原菌分布,探讨患者感染后血清炎性因子水平变化以及与感染的相关性。方法分析2015年1月-2016年6月在医院接受就诊的147例糖尿病足患者的临床资料,依据患者是否并发感染将患者分为感染组71例及非感染组76例,同时纳入同期健康体检者作为对照组82例,进行病原菌鉴定分型,比较各组外周血炎症指标。结果 71例感染组患者共分离致病菌91株,以革兰阴性菌为主,共52株占57.1%;感染组与非感染组患者外周血肿瘤坏死因子-α(TNF-α)、白介素-7(IL-17)、白介素-6(IL-6)水平均高于对照组(P0.05);感染组患者外周血TNF-α、IL-17、IL-6水平均高于非感染组(P0.05);相关性分析显示,糖尿病足病感染患者严重程度与血清IL-6、IL-17、TNF-α水平呈正相关关系。结论感染性糖尿病足患者以革兰阴性菌感染为主,并且患者感染后TNF-α、IL-17、IL-6水平高于非感染组,且随着病情的严重程度而升高。
[Abstract]:Objective to detect the distribution of pathogenic bacteria in patients with type 2 diabetes mellitus complicated with diabetic foot infection, and to explore the changes of serum inflammatory factors and their correlation with infection in patients with type 2 diabetes mellitus (T2DM). Methods the clinical data of 147 patients with diabetic foot who received medical treatment in hospital from January 2015 to June 2016 were analyzed. According to whether the patients were complicated with infection or not, the patients were divided into infection group (71 cases) and non-infection group (76 cases). At the same time, 82 cases were included in healthy body examination as control group. The pathogenic bacteria were identified and classified, and the indexes of peripheral blood inflammation in each group were compared. Results 91 strains of pathogenic bacteria were isolated from 71 patients with infection, 52 strains (57.1%) were Gram-negative bacteria, the levels of tumor necrosis factor-伪 (TNF- 伪), IL-7 (IL-17) and IL-6 (IL-6) in peripheral blood of patients in infection group and non-infection group were higher than those in control group (P 0.05), and the levels of TNF- 伪 and IL-17,IL-6 in peripheral blood of patients in infection group were higher than those in non-infection group (P 0.05). Correlation analysis showed that there was a positive correlation between the severity of diabetic foot infection and serum IL-6,IL-17,TNF- 伪 level. Conclusion Gram-negative bacteria infection is the main infection in infectious diabetic foot patients, and the levels of TNF- 伪 and IL-17,IL-6 after infection are higher than those in non-infection group, and increase with the severity of the disease.
【作者单位】：武汉理工大学医院内分泌科;武汉市第八医院心血管内科;广州军区武汉总医院内分泌科;武汉理工大学医院内科;
【基金】：湖北省科技厅攻关基金资助项目(20002P1015)
【分类号】：R587.2

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