Anti-inflammatory properties of lipoxin A4 protect against d

发布时间：2021-09-24 20:14

　　Lipoxin A4 can alleviate cerebral ischemia/reperfusion injury by reducing the inflammatory reaction,but it is currently unclear whether it has a protective effect on diabetes mellitus complicated by focal cerebral ischemia/reperfusion injury.In this study,we established rat models of diabetes mellitus using an intraperitoneal injection of streptozotocin.We then induced focal cerebral ischemia/reperfusion injury by occlusion of the middle cerebral artery for 2 hours and reperfusion for 24 hours.A... 

【文章来源】：Neural Regeneration Research. 2016,11(04)SCICSCD

【文章页数】：5 页

【文章目录】：
Graphical Abstract
Introduction
Materials and Methods
    Ethics statement and experimental animals
    Induction of DM
    Establishment of rat models of focal cerebral I/R injury
    LXA4 administration
    Neurological deficit evaluation
    Infarct volume
    Western blot assay
    Statistical analysis
Results
    LXA4 improved the neurological function of diabetic rats with cerebral I/R injury
    LXA4 reduced the brain infarct volume in diabetic rats with cerebral I/R injury
    LXA4 decreased TNF-αand NF-κB expression in the cerebral cortex of diabetic rats with cerebral I/R injury
Discussion



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