Th细胞相关细胞因子水平与老年湿疹患者临床特征的相关分析

发布时间：2018-01-02 12:05

本文关键词：Th细胞相关细胞因子水平与老年湿疹患者临床特征的相关分析　出处：《中国皮肤性病学杂志》2016年12期 　论文类型：期刊论文

【摘要】：目的研究老年湿疹患者血清辅助性T细胞因子的水平及其与湿疹临床特征的相关性。方法收集2013年9月-2015年9月在我科确诊为老年湿疹患者60例的临床资料,并选取健康对照组40例。采用酶联免疫吸附法(ELISA)检测血清中Th的特征细胞因子γ-干扰素(INF-γ)、白介素-4(IL-4)及白介素-17A(IL-17A)的表达水平,分别比较Th细胞相关因子在急慢性,或泛发和局限型湿疹中的差异。结果与老年健康对照组相比,老年湿疹患者血清IFN-γ,IL-4,IL-17A显著升高(P均0.001)。其中老年急性湿疹患者血清IFN-γ,IL-4及IL-17A显著高于慢性期(P均0.001);泛发型患者血清IFN-γ,IL-4及IL-17A明显高于局限型(P均0.05)。结论血清IFN-γ,IL-4及IL-17A可能参与老年湿疹的进展与预后,并且Th细胞相关因子表达的不同可能作为反映临床类型的指标。
[Abstract]:Objective to study the level of serum helper T cytokines in elderly patients with eczema and its correlation with the clinical features of eczema. Methods 60 cases of senile eczema diagnosed in our department from September 2013 to September 2015 were collected. Cases of clinical data. The serum Th characteristic cytokines (IFN- 纬) were detected by Elisa in 40 healthy controls. The expression levels of IL-4 and IL-17A) were compared in acute and chronic cases. Results Serum IFN- 纬 IL-4 levels in elderly patients with eczema were higher than those in healthy controls. The levels of serum IFN- 纬 IL-4 and IL-17A in middle and old patients with acute eczema were significantly higher than those in patients with chronic eczema. The levels of serum IFN- 纬 IL-4 and IL-17A were significantly higher in generalized patients than those in localized patients (P 0.05). Conclusion Serum IFN- 纬. IL-4 and IL-17A may be involved in the progression and prognosis of eczema in the elderly, and the different expression of Th cytokines may be used as a marker to reflect the clinical type of eczema.
【作者单位】：北京市丰台中西医结合医院;
【分类号】：R758.23
【正文快照】： 湿疹是临床上常见的炎症性皮肤病,各年龄阶段均可发生,但以老年人多见。本病病理机制复杂,其中免疫紊乱、失衡是目前研究热点。T辅助细胞1/2(Th1/Th2)产生免疫因子的动态平衡是湿疹疾病过程中的重要因素[1]。Th1细胞分泌INF-γ、白介素-2(IL-2)及肿瘤坏死因子(TNF-α),Th2细胞

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