氟哌噻吨美利曲新联合加巴喷丁和甲钴胺治疗老年带状疱疹后神经痛的临床疗效观察

发布时间：2018-01-03 17:42

本文关键词：氟哌噻吨美利曲新联合加巴喷丁和甲钴胺治疗老年带状疱疹后神经痛的临床疗效观察　出处：《重庆医学》2015年35期 　论文类型：期刊论文

【摘要】：目的观察氟哌噻吨美利曲新联合加巴喷丁和甲钴胺治疗老年带状疱疹后神经痛的临床疗效。方法选择老年带状疱疹后神经痛患者60例,分为治疗组和对照组各30例。两组患者均给予口服加巴喷丁胶囊和甲钴胺片治疗,治疗组在此基础上加用氟哌噻吨美利曲新治疗,疗程均为4周。分别于治疗前、治疗后1、2、3、4周进行视觉模拟评分(VAS)、睡眠质量评分(PSQI)及医院焦虑抑郁量表(HAD)评分,并计算有效率来评价疗效。结果两组患者接受治疗后VAS评分、PSQI评分、HAD评分均有明显下降,与对照组比较,治疗组下降更明显,两组患者在治疗后2、3、4周比较差异有统计学意义(P0.05);用药后1、2、3、4周治疗组的有效率分别为28.98%、53.32%、70.65%、89.54%,对照组分别为22.25%、35.14%、51.78%、60.56%,治疗组均高于对照组,在用药后2、3、4周两组间比较差异有统计学意义(P0.05)。两组患者均未见明显不良反应发生。结论氟哌噻吨美利曲新联合加巴喷丁和甲钴胺治疗老年带状疱疹后神经痛疗效较好,且安全。
[Abstract]:Objective to observe the clinical effect of droperazothioate trimetrixine combined with gabapentine and mecobalamin in the treatment of postherpetic neuralgia in the elderly. Methods 60 elderly patients with postherpetic neuralgia were selected. Each group was divided into two groups: 30 cases in the treatment group and 30 cases in the control group. The patients in both groups were treated with oral gabapentin capsule and methylcobalamin tablet. The course of treatment was 4 weeks. Visual analogue scale (VASA), sleep quality score (PSQI) and hospital anxiety and depression scale (HAD-HAD) were performed before and after treatment. Results the VAS scores and VAS scores and had scores were significantly decreased in the two groups after treatment, compared with the control group, the decrease was more obvious in the treatment group than in the control group. There was a significant difference between the two groups at 2 and 3 weeks after treatment (P 0.05). The effective rates of the treatment group were 28.98% and 53.32%, respectively, and that of the control group were 22.25% and 35.14%, respectively. The treatment group was higher than the control group. The difference between the two groups in 4 weeks was statistically significant (P 0.05). There were no obvious adverse reactions in the two groups. Conclusion the efficacy of droperazothioate metrexacin combined with gabapentine and methylcobalamin in the treatment of postherpetic neuralgia in elderly patients is better. And safe.
【作者单位】：江西省宜春市人民医院神经内科;
【分类号】：R752.12
【正文快照】： 带状疱疹皮损消退后,其受累区皮肤出现疼痛持续1个月以上的患者可以诊断为带状疱疹后神经痛,多发于60岁以上的老年人[1]。临床表现为钻痛、刺痛、烧灼样痛、电击样疼痛,常疼痛难忍,严重影响患者的生活质量和睡眠。患者常伴有情绪低落和烦躁不安,有些患者甚至产生轻生的念头。

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