阿维A与氨甲蝶呤治疗重度斑块型银屑病的疗效

发布时间：2018-01-05 23:11

本文关键词：阿维A与氨甲蝶呤治疗重度斑块型银屑病的疗效　出处：《中南大学学报(医学版)》2016年08期 　论文类型：期刊论文

【摘要】：目的:观察阿维A与氨甲蝶呤治疗重度斑块型银屑病的疗效。方法:54例确诊为斑块型银屑病的患者被分为阿维A组(32例,口服阿维A30 mg,每日1次)和氨甲蝶呤组(22例,口服氨甲蝶呤15 mg,每周1次),均外用卡泊三醇软膏和硼酸软膏,疗程8周。以银屑病面积和严重度指数(psoriasis area and severity index,PASI)作为观察指标,比较两种药物的疗效。结果:治疗后,阿维A组和氨甲蝶呤组PASI评分均较治疗前下降(P0.001),PASI评分改善率和PASI评分有效率在两组间比较差异均无统计学意义(均P0.05)。结论:阿维A或氨甲蝶呤治疗重度斑块型银屑病均有效,且疗效相当。
[Abstract]:Objective: to observe the efficacy of Avera and methotrexate in the treatment of severe plaque psoriasis. Methods: Fifty-four patients with severe plaque psoriasis were divided into two groups: group A (n = 32) and group A (n = 32). Methotrexate group (n = 22) and methotrexate group (n = 22) were treated with carpotriol ointment and boric acid ointment by oral methotrexate 15 mg once a week. The psoriasis area and severity index (PASI) was used as the index of psoriasis area and severity. Results: after treatment, the PASI scores in group A and group A were significantly lower than those before treatment (P 0.001). There was no significant difference in the improvement rate of PASI score and the effective rate of PASI score between the two groups (all P0.050.Conclusion: Avera or methotrexate are effective in the treatment of severe plaque psoriasis. And the curative effect is similar.
【作者单位】：中南大学湘雅医院皮肤科;
【基金】：湖南省财政厅湖南卫生项目(2100201) 湖南省科技厅科技计划项目(2013FJ6004)~~
【分类号】：R758.63
【正文快照】： 第一作者(First author):刘盼盼,Email:liupanpan91@hotmail.com斑块型银屑病是以红斑、鳞屑、浸润为改变的慢性炎症性皮肤病,近年来该病在我国的发病率呈上升趋势[1],其反复发作的特点严重影响着患者的身心健康[2]。阿维A和氨甲蝶呤均为治疗重度斑块型银屑病的一线用药[3],但

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