Stevens-Johnson综合征的治疗及预后:38例回顾性分析

发布时间：2018-01-06 04:41

本文关键词：Stevens-Johnson综合征的治疗及预后:38例回顾性分析　出处：《中国皮肤性病学杂志》2016年08期 　论文类型：期刊论文

【摘要】：目的探讨药物诱发性Stevens-Johnson综合征的治疗及预后。方法回顾性分析38例药物诱发性Stevens-Johnson综合征住院患者的临床和实验室资料、治疗及预后。结果前三类致病药物包括抗生素、非甾体抗炎药和卡马西平。29例静脉应用糖皮质激素(甲泼尼龙)治疗,9例静脉用免疫球蛋白和糖皮质激素联合治疗。联合治疗组的平均起始日激素剂量、出院时日激素剂量、累积激素剂量(均为泼尼松相当量)均明显低于糖皮质激素组(P=0.001,0.001和0.025)。38例患者均治愈。单用激素组中,2例继发口腔真菌感染,1例合并急性胰腺炎,1例并发慢性角膜炎;联合治疗组未观察到不良反应或并发症。结论糖皮质激素疗法和免疫球蛋白-皮质激素联合疗法治疗Stevens-Johnson综合征均有效,并且联合疗法糖皮质激素用量明显减少。
[Abstract]:Objective to investigate the treatment and prognosis of drug-induced Stevens-Johnson syndrome. Methods 38 cases of drug-induced Stevens-Johnson syndrome were retrospectively analyzed. Clinical and laboratory data. Results the first three kinds of pathogenic drugs included antibiotics, non-steroidal anti-inflammatory drugs and carbamazepine. 29 cases were treated with glucocorticoid (methylprednisolone). Nine patients were treated with the combination of immunoglobulin and glucocorticoid. The cumulative dose of prednisone (prednisone equivalent) was significantly lower than that in glucocorticoid group (0.001 / 0.001) and 0.025 / 38 (n = 38). There were 2 cases of secondary oral fungal infection and 1 case of acute pancreatitis and 1 case of chronic keratitis. Conclusion both glucocorticoid therapy and immunoglobulin-corticosteroid therapy are effective in the treatment of Stevens-Johnson syndrome. The dosage of glucocorticoid in combination therapy was significantly reduced.
【作者单位】：中国医科大学附属第一医院皮肤科;广西壮族自治区皮肤病防治研究所;
【基金】：教育部新世纪优秀人才支持计划(NCET-10-0905)
【分类号】：R758.25
【正文快照】： 药物诱发性Stevens-Johnson综合征(SJS)是一种急性的、严重的、可危及生命的大疱性皮肤黏膜反应。国外报告SJS的年发病率为2.6~7.1例/百万,死亡率为1%~10%[1]。现对本科收治的38例药物诱发性SJS患者的临床和实验室资料、治疗和预后进行回顾性分析。1资料与方法2009年1月-2013

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