透明质酸修护生物膜联合吡美莫司乳膏对面部糖皮质激素依赖性皮炎的疗效观察

发布时间：2018-01-08 00:18

本文关键词：透明质酸修护生物膜联合吡美莫司乳膏对面部糖皮质激素依赖性皮炎的疗效观察　出处：《临床皮肤科杂志》2016年06期 　论文类型：期刊论文

【摘要】：目的:观察透明质酸修护生物膜联合吡美莫司治疗面部糖皮质激素依赖性皮炎的疗效。方法:将患者按就诊的登记号单双号分组,按试验标准进行筛选排除后,试验组62例,对照组50例纳入统计。试验组患者外用透明质酸修护生物膜联合吡美莫司连续治疗4周,后4周停用吡美莫司,每日外用透明质酸修护生物膜2次。对照组患者仅外用吡美莫司治疗4周,停药后观察4周。分别于治疗前和治疗第2、4、8周进行疗效评估,测定皮肤生理指标并观察复发情况。结果:治疗2周时试验组痊愈率高于对照组(P0.05),两组显效率差异无统计学意义;治疗第4周试验组痊愈率和显效率均高于对照组(P均0.05)。治疗第2、4、8周后,试验组经皮水分丢失(TEWL)值均低于对照组,而角质层含水量(WCSC)均高于对照组(P均0.05)。治疗第8周试验组复发率(6.45%)低于对照组(18%)(P0.05)。结论:外用透明质酸修护生物膜联合吡美莫司治疗面部糖皮质激素依赖性皮炎疗效优于单纯外用吡美莫司,且降低复发率。
[Abstract]:Objective: To observe the therapeutic effect of hyaluronic acid membrane repair combined with pimecrolimus in the treatment of facial corticosteroid dependent dermatitis. Methods: the patients according to the registration number of single packet, according to the standard screening test were excluded, 62 cases of test group and control group of 50 cases included in the statistics. The experimental group were treated with hyaluronic acid repair biofilm and pimecrolimus treated for 4 weeks, 4 weeks after discontinuation of pimecrolimus, daily topical hyaluronic acid membrane repair 2 times. The control group were only topical pimecrolimus in the treatment of 4 weeks after discontinuation of treatment for 4 weeks. The curative effect was evaluated before treatment and at 2,4,8 weeks respectively. Determination of physiological index of the skin and the recurrence were observed after 2 weeks of treatment. Results: the cure rate of the experimental group was higher than that of the control group (P0.05), the two group was no significant difference; after fourth weeks of treatment, experimental group cure rate and effective rate were higher than the control group (P 0.05) in second, After 4,8 weeks, the experimental group of transepidermal water loss (TEWL) values were lower than the control group, while the water content of stratum corneum (WCSC) were higher than the control group (P < 0.05). After eighth weeks of treatment, the recurrence rate of experimental group (6.45%) than in the control group (18%) (P0.05). Conclusion: hyaluronic acid repair biofilm and pimecrolimus in the treatment of facial corticosteroid dependent dermatitis efficacy than simple topical pimecrolimus, and reduce the recurrence rate.

【作者单位】：潍坊医学院临床学院;潍坊市人民医院皮肤科;
【分类号】：R758.25
【正文快照】： 糖皮质激素依赖性皮炎是皮肤科常见病,主要表现为局部表皮萎缩、毛细血管扩张以及反复炎症反应等造成皮肤的屏障功能受损[1]。当皮肤屏障功能受损时,经表皮水分流失(TEWL)增加,皮肤角质层含水量(WCSC)降低,加重糖皮质激素依赖性皮炎的症状。我们在临床中应用薇诺娜透明质酸

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