不同类型重症药疹患者外周血淋巴细胞亚群分析及其临床意义

发布时间：2018-02-07 08:49

本文关键词： 淋巴细胞重症药疹流式细胞术治疗　出处：《南京医科大学学报(自然科学版)》2014年06期 　论文类型：期刊论文

【摘要】：目的:检测不同类型重症药疹患者外周血淋巴细胞亚群并研究其临床意义。方法:采用免疫荧光标记流式细胞术检测21例重症药疹患者外周血淋巴细胞的表型。结果:药物超敏反应综合征(drug-induced hypersensitivity syndrome,DIHS)患者治疗前CD3+、CD3+CD4+淋巴细胞较正常值显著增加,并且DIHS患者治疗前CD3+CD4+淋巴细胞显著高于Stevens-Johnson综合征(Stevens-Johnson syndrome,SJS)和中毒性表皮坏死松解症(toxic epidermal necrolysis,TEN)患者;在SJS和TEN患者中,随着外周血CD3+CD4+、CD3+CD8+淋巴细胞数目的增加,激素最大控制用量逐渐减少,随着外周血CD3-CD16+CD56+淋巴细胞数目的增加,激素最大控制用量逐渐增加。结论:不同类型的重症药疹外周血淋巴细胞亚群不同,外周血不同类型淋巴细胞亚群对激素最大控制用量的影响不同。
[Abstract]:Objective: to study the clinical significance of lymphocyte subsets in peripheral blood of patients with different types of severe drug rash. Methods: the phenotypes of peripheral blood lymphocytes in 21 patients with severe drug rash were detected by immunofluorescence flow cytometry (FCM). Results: the CD3 CD4 lymphocytes of CD3 were significantly increased in patients with drug hypersensitivity syndrome (DHS) before treatment. The number of CD3 CD4 lymphocytes in patients with DIHS was significantly higher than that in patients with Stevens-Johnson syndrome (Stevens-Johnson syndrome SJS) and toxic epidermal necrotic necrolysis syndrome (TEN) before treatment, and in SJS and TEN patients, the number of CD3 CD8 lymphocytes increased with the increase of CD3 CD4 in peripheral blood. With the increase of the number of CD3-CD16 CD56 lymphocytes in peripheral blood, the maximum control dose of hormone gradually increased. Conclusion: different types of severe drug rash have different lymphocyte subsets in peripheral blood. The effects of lymphocyte subsets of different types of peripheral blood on the maximum controlled dose of hormone were different.
【作者单位】：南京医科大学第一附属医院皮肤科;南京医科大学第一附属医院肿瘤科;
【基金】：国家自然科学基金(81171517)
【分类号】：R758.25

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