不同病程尖锐湿疣患者HPV感染和淋巴细胞免疫功能分析

发布时间：2018-02-13 05:09

本文关键词： 尖锐湿疣人乳头瘤病毒亚型细胞免疫功能　出处：《中国艾滋病性病》2017年12期 　论文类型：期刊论文

【摘要】：目的分析不同病程尖锐湿疣(CA)患者感染人乳头瘤病毒(HPV)亚型情况和细胞免疫功能。方法收集CA患者468例,设立病程3个月的258例患者为A组,3个月的210例患者为B组,同时设立对照组30例。CA患者取疣体细胞进行HPV-脱氧核糖核酸(DNA)分型检测,抽取静脉血检测淋巴细胞亚群和艾滋病病毒抗体。对照组取泌尿生殖系统脱落细胞,并抽取静脉血,检测同CA患者。结果 468例CA患者中,HPV亚型检出率由高到低依次HPV6(34.2%),HPV11(26.5%),HPV52(12.0%)、HPV16(10.3%)。A、B两组患者共检出HPV亚型阳性结果为754个,低危型321个,占42.6%,高危型433个,占57.4%。A组364个,其中低危型180个(49.5%),高危型184个(50.5%);B组390个,其中低危型141个(36.2%),高危型249个(63.8%)。B组患者多重感染比例为43.8%(92/210),A组为27.1%(70/258),差异有统计学意义(χ2=14.23,P0.01)。CA患者CD4+、CD4+/CD8+低于对照组,CD8+高于对照组,其中B组显示的差异更为显著。结论 HPV高危亚型感染以及与高危亚型合并的多重感染,同时机体细胞免疫功能低下是CA复发的重要因素。
[Abstract]:Objective to analyze the subtypes and cellular immune function of human papillomavirus (HPV) infection in patients with CAA with different course of disease. Methods A group of 258 patients with 3 months course of disease and 210 patients with 3 months course of disease were selected as group B and 468 patients with CA. At the same time, 30 patients with CA in the control group were selected to take out warts cells for HPV-DNA DNA typing, and venous blood was extracted to detect lymphocyte subsets and HIV antibodies, while the control group took exfoliated cells from the genitourinary system and extracted venous blood. Results in 468 patients with CA, the positive rate of HPV subtype was 754, 321 low, 42.6, 433 high-risk type, 57.44.A, 57.40.The positive rate of HPV subtype was 754, 321 low risk type, 42.6%, 42.6%, 42.6%, 42.6%, 42.6%, 42.6%, 42.6%, respectively, and the positive results of HPV subtype were 754, 42.6, 57.44.A, 57.44.The positive results were 754, 321 low risk type, 42.6%, 42.6%, 42.6%, 42.6%, 42.6% and 42.6%, respectively, in 468 patients with CA. Among them, 180 cases of low risk type were 49.55%, 184 cases of high risk type (184 cases) were divided into group B (390 cases), there were 141 cases with low risk type (36.2%) and 249 cases with high risk type (group B with 63.8%). The rate of multiple infection in group B was 43.82%. The ratio of multiple infection in group A was 27.1% 70% 258U, the difference was statistically significant (蠂 2, 14.23%, P 0.01A, CA, P 0.01M, CA), and the ratio of CD4 / CD8 in patients with CD4 / CD8 was lower than that in control group (P < 0.05), but the ratio of CD 4 / CD 8 in group B was significantly lower than that in group B (P < 0.05). Conclusion HPV high risk subtype infection and multiple infection combined with high risk subtype, and low cellular immune function are important factors for CA recurrence.
【作者单位】：广州市皮肤病防治所;
【分类号】：R752.53

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